Mechanism of Holliday junction resolution by the human GEN1 protein

Holliday junction (HJ) resolution is essential for chromosome segregation at meiosis and the repair of stalled/collapsed replication forks in mitotic cells. All organisms possess nucleases that promote HJ resolution by the introduction of symmetrically related nicks in two strands at, or close to, t...

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Veröffentlicht in:	Genes & development 2010-07, Vol.24 (14), p.1559-1569
Hauptverfasser:	Rass, Ulrich, Compton, Sarah A, Matos, Joao, Singleton, Martin R, Ip, Stephen C Y, Blanco, Miguel G, Griffith, Jack D, West, Stephen C
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Repair DNA, Cruciform - metabolism Endodeoxyribonucleases - metabolism Escherichia coli Proteins - metabolism Flap Endonucleases - metabolism Holliday Junction Resolvases - chemistry Holliday Junction Resolvases - metabolism Humans Research Paper Substrate Specificity
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