Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

Pre-rRNA transcription by RNA Polymerase I (Pol I) is very robust on active rDNA repeats. Loss of yeast Topoisomerase I (Top1) generated truncated pre-rRNA fragments, which were stabilized in strains lacking TRAMP (Trf4/Trf5-Air1/Air2-Mtr4 polyadenylation complexes) or exosome degradation activities...

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Veröffentlicht in:	Genes & development 2010-07, Vol.24 (14), p.1546-1558
Hauptverfasser:	El Hage, Aziz, French, Sarah L, Beyer, Ann L, Tollervey, David
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Topoisomerases, Type I - metabolism Research Paper Ribonuclease H - metabolism RNA Precursors - genetics RNA, Ribosomal, 18S - genetics Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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