Regulation of Adipogenesis by Natural and Synthetic REV-ERB Ligands

The nuclear hormone receptor, REV-ERB, plays an essential role in adipogenesis. Rev-erbα expression is induced in 3T3-L1 cells during adipogenesis, and overexpression of this receptor leads to expression of adipogenic genes. We recently demonstrated that the porphyrin heme functions as a ligand for...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2010-07, Vol.151 (7), p.3015-3025
Hauptverfasser:	Kumar, Naresh, Solt, Laura A, Wang, Yongjun, Rogers, Pamela M, Bhattacharyya, Gargi, Kamenecka, Theodore M, Stayrook, Keith R, Crumbley, Christine, Floyd, Z. Elizabeth, Gimble, Jeffrey M, Griffin, Patrick R, Burris, Thomas P
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells 5-Aminolevulinate Synthetase - genetics 5-Aminolevulinate Synthetase - metabolism Adipocytes Adipogenesis Adipogenesis - drug effects Adipogenesis - genetics Aminolevulinic acid Animals Biological and medical sciences Biosynthesis Blotting, Western Cell differentiation Cell Differentiation - drug effects Chromatin Immunoprecipitation Differentiation Fundamental and applied biological sciences. Psychology Heme Heme - pharmacology Ligands Metabolic disorders Mice Nuclear Receptor Subfamily 1, Group D, Member 1 - agonists Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism Porphyrins Receptors RNA, Small Interfering Rosiglitazone Thiazolidinediones - pharmacology Vertebrates: endocrinology
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