Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice

Natural killer (NK) cells play crucial roles in innate immunity and express CD39 (Ecto‐nucleoside triphosphate diphosphohydrolase 1 [E‐NTPD1]), a rate‐limiting ectonucleotidase in the phosphohydrolysis of extracellular nucleotides to adenosine. We have studied the effects of CD39 gene deletion on NK...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2010-05, Vol.51 (5), p.1702-1711
Hauptverfasser:	Beldi, Guido, Banz, Yara, Kroemer, Alexander, Sun, Xiaofeng, Wu, Yan, Graubardt, Nadine, Rellstab, Alyssa, Nowak, Martina, Enjyoji, Keiichi, Li, Xian, Junger, Wolfgang G., Candinas, Daniel, Robson, Simon C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Animals Antigens, CD - metabolism Apyrase - deficiency Apyrase - metabolism Biological and medical sciences Cytokines Gastroenterology. Liver. Pancreas. Abdomen Hepatology Ischemia Killer Cells, Natural - immunology Killer Cells, Natural - physiology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Mice, Inbred C57BL Other diseases. Semiology Receptors, Purinergic P2 - physiology Reperfusion Injury - prevention & control Rodents
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