Obstructive Sleep Apnea Syndrome Is Associated with Deficits in Verbal but Not Visual Memory
Although cognitive deficits are well documented in patients with sleep apnea, the impact on memory remains unclear. To test the hypotheses that (1) patients with obstructive sleep apnea have memory impairment and (2) memory impairment is commensurate with disease severity. Patients with obstructive...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2010-07, Vol.182 (1), p.98-103 |
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| creator | TWIGG, Gillian L PAPAIOANNOU, Loannis JACKSON, Melinda GHIASSI, Ramesh SHAIKH, Zarrin JAYE, Jay GRAHAM, Kim S SIMONDS, Anita K MORRELL, Mary J |
| description | Although cognitive deficits are well documented in patients with sleep apnea, the impact on memory remains unclear.
To test the hypotheses that (1) patients with obstructive sleep apnea have memory impairment and (2) memory impairment is commensurate with disease severity.
Patients with obstructive sleep apnea and healthy volunteers (apnea-hypopnea index |
| doi_str_mv | 10.1164/rccm.200901-0065OC |
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To test the hypotheses that (1) patients with obstructive sleep apnea have memory impairment and (2) memory impairment is commensurate with disease severity.
Patients with obstructive sleep apnea and healthy volunteers (apnea-hypopnea index <5 events/h) completed a test battery specially designed to differentiate between aspects of memory (semantic, episodic, and working) versus attention. Sleepiness was measured on the basis of the Epworth Sleepiness Scale and Oxford Sleep Resistance test. Memory performance in patients versus control subjects was compared (Mann-Whitney U test; P < 0.01, Bonferroni corrected for multiple comparisons) and relationships between performance and disease severity were analyzed by linear regression.
Sixty patients and healthy control subjects matched for age (mean +/- SD: patients, 51 +/- 9 yr; control subjects, 50 +/- 9 yr) and education (patients, 14 +/- 3 yr; control subjects, 15 +/- 3 yr) participated. Patients demonstrated impaired Logical Memory Test results (immediate recall: patients, median [range], 36 [9-69]; control subjects, 43 [19-64], P = 0.0004; and delayed recall: patients, 22 [6-42]; control subjects, 27 [10-46]; P = 0.0001). There were minimal differences in attention, visual episodic, semantic, or working memory; patients performed better than control subjects on Spatial Span forward and backward. Regression analysis revealed that Logical Memory Test performance was not significantly related to disease severity after controlling for age, education, and sleepiness.
Obstructive sleep apnea is associated with impairment in verbal, but not visual, memory. The impairment was present across a range of disease severity and was not explained by reduced attention. Such verbal memory impairment may affect daytime functioning and performance.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200901-0065OC</identifier><identifier>PMID: 20299536</identifier><language>eng</language><publisher>New York, NY: American Thoracic Society</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Case-Control Studies ; Chronic obstructive pulmonary disease, asthma ; Cognitive ability ; Female ; G. Sleep and Control of Ventilation ; Health care ; Humans ; Hypotheses ; Intensive care medicine ; Male ; Mann-Whitney U test ; Medical sciences ; Memory ; Memory Disorders - etiology ; Mental Recall ; Patients ; Pattern Recognition, Visual ; Pneumology ; Polysomnography ; Regression analysis ; Semantics ; Sleep apnea ; Sleep Apnea, Obstructive - complications ; Verbal Learning</subject><ispartof>American journal of respiratory and critical care medicine, 2010-07, Vol.182 (1), p.98-103</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Thoracic Society Jul 1, 2010</rights><rights>Copyright © 2010, American Thoracic Society 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-f40f82ee0916d7e8012f33667628f8ea0bb7e17207b96c85b1e55155dc3a48833</citedby><cites>FETCH-LOGICAL-c507t-f40f82ee0916d7e8012f33667628f8ea0bb7e17207b96c85b1e55155dc3a48833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4025,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22999367$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20299536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TWIGG, Gillian L</creatorcontrib><creatorcontrib>PAPAIOANNOU, Loannis</creatorcontrib><creatorcontrib>JACKSON, Melinda</creatorcontrib><creatorcontrib>GHIASSI, Ramesh</creatorcontrib><creatorcontrib>SHAIKH, Zarrin</creatorcontrib><creatorcontrib>JAYE, Jay</creatorcontrib><creatorcontrib>GRAHAM, Kim S</creatorcontrib><creatorcontrib>SIMONDS, Anita K</creatorcontrib><creatorcontrib>MORRELL, Mary J</creatorcontrib><title>Obstructive Sleep Apnea Syndrome Is Associated with Deficits in Verbal but Not Visual Memory</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Although cognitive deficits are well documented in patients with sleep apnea, the impact on memory remains unclear.
To test the hypotheses that (1) patients with obstructive sleep apnea have memory impairment and (2) memory impairment is commensurate with disease severity.
Patients with obstructive sleep apnea and healthy volunteers (apnea-hypopnea index <5 events/h) completed a test battery specially designed to differentiate between aspects of memory (semantic, episodic, and working) versus attention. Sleepiness was measured on the basis of the Epworth Sleepiness Scale and Oxford Sleep Resistance test. Memory performance in patients versus control subjects was compared (Mann-Whitney U test; P < 0.01, Bonferroni corrected for multiple comparisons) and relationships between performance and disease severity were analyzed by linear regression.
Sixty patients and healthy control subjects matched for age (mean +/- SD: patients, 51 +/- 9 yr; control subjects, 50 +/- 9 yr) and education (patients, 14 +/- 3 yr; control subjects, 15 +/- 3 yr) participated. Patients demonstrated impaired Logical Memory Test results (immediate recall: patients, median [range], 36 [9-69]; control subjects, 43 [19-64], P = 0.0004; and delayed recall: patients, 22 [6-42]; control subjects, 27 [10-46]; P = 0.0001). There were minimal differences in attention, visual episodic, semantic, or working memory; patients performed better than control subjects on Spatial Span forward and backward. Regression analysis revealed that Logical Memory Test performance was not significantly related to disease severity after controlling for age, education, and sleepiness.
Obstructive sleep apnea is associated with impairment in verbal, but not visual, memory. The impairment was present across a range of disease severity and was not explained by reduced attention. Such verbal memory impairment may affect daytime functioning and performance.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cognitive ability</subject><subject>Female</subject><subject>G. Sleep and Control of Ventilation</subject><subject>Health care</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Mann-Whitney U test</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Memory Disorders - etiology</subject><subject>Mental Recall</subject><subject>Patients</subject><subject>Pattern Recognition, Visual</subject><subject>Pneumology</subject><subject>Polysomnography</subject><subject>Regression analysis</subject><subject>Semantics</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Verbal Learning</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkU1v1DAQhiNERT_gD3BAFhLqKWVsx3ZyQVotH61U2EOh4oBkOc6EukrixXaK9t_j1W5b4DQe-Zl33tFbFC8pnFEqq7fB2vGMATRASwApVssnxREVXJRVo-BpfoPiZVU13w-L4xhvASirKTwrDhmwphFcHhU_Vm1MYbbJ3SG5GhDXZLGe0JCrzdQFPyK5iGQRo7fOJOzIb5duyHvsnXUpEjeRawytGUg7J_LFJ3Lt4pzbzzj6sHleHPRmiPhiX0-Kbx8_fF2el5erTxfLxWVpBahU9hX0NUOEhspOYZ1t9pxLqSSr-xoNtK1CqhiotpG2Fi1FIagQneWmqmvOT4p3O9313I7YWZxSMINeBzeasNHeOP3vz-Ru9E9_p1kDLG_JAqd7geB_zRiTHl20OAxmQj9HrbIdLiiDTL7-j7z1c5jydVpsjYu62vphO8gGH2PA_sEKBb2NTm-j07vo9C66PPTq7yMeRu6zysCbPWCiNUMfzGRdfOQy1nCp-B8rq6Jq</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>TWIGG, Gillian L</creator><creator>PAPAIOANNOU, Loannis</creator><creator>JACKSON, Melinda</creator><creator>GHIASSI, Ramesh</creator><creator>SHAIKH, Zarrin</creator><creator>JAYE, Jay</creator><creator>GRAHAM, Kim S</creator><creator>SIMONDS, Anita K</creator><creator>MORRELL, Mary J</creator><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100701</creationdate><title>Obstructive Sleep Apnea Syndrome Is Associated with Deficits in Verbal but Not Visual Memory</title><author>TWIGG, Gillian L ; PAPAIOANNOU, Loannis ; JACKSON, Melinda ; GHIASSI, Ramesh ; SHAIKH, Zarrin ; JAYE, Jay ; GRAHAM, Kim S ; SIMONDS, Anita K ; MORRELL, Mary J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-f40f82ee0916d7e8012f33667628f8ea0bb7e17207b96c85b1e55155dc3a48833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Cognitive ability</topic><topic>Female</topic><topic>G. Sleep and Control of Ventilation</topic><topic>Health care</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Mann-Whitney U test</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Memory Disorders - etiology</topic><topic>Mental Recall</topic><topic>Patients</topic><topic>Pattern Recognition, Visual</topic><topic>Pneumology</topic><topic>Polysomnography</topic><topic>Regression analysis</topic><topic>Semantics</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Verbal Learning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TWIGG, Gillian L</creatorcontrib><creatorcontrib>PAPAIOANNOU, Loannis</creatorcontrib><creatorcontrib>JACKSON, Melinda</creatorcontrib><creatorcontrib>GHIASSI, Ramesh</creatorcontrib><creatorcontrib>SHAIKH, Zarrin</creatorcontrib><creatorcontrib>JAYE, Jay</creatorcontrib><creatorcontrib>GRAHAM, Kim S</creatorcontrib><creatorcontrib>SIMONDS, Anita K</creatorcontrib><creatorcontrib>MORRELL, Mary J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TWIGG, Gillian L</au><au>PAPAIOANNOU, Loannis</au><au>JACKSON, Melinda</au><au>GHIASSI, Ramesh</au><au>SHAIKH, Zarrin</au><au>JAYE, Jay</au><au>GRAHAM, Kim S</au><au>SIMONDS, Anita K</au><au>MORRELL, Mary J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obstructive Sleep Apnea Syndrome Is Associated with Deficits in Verbal but Not Visual Memory</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>182</volume><issue>1</issue><spage>98</spage><epage>103</epage><pages>98-103</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Although cognitive deficits are well documented in patients with sleep apnea, the impact on memory remains unclear.
To test the hypotheses that (1) patients with obstructive sleep apnea have memory impairment and (2) memory impairment is commensurate with disease severity.
Patients with obstructive sleep apnea and healthy volunteers (apnea-hypopnea index <5 events/h) completed a test battery specially designed to differentiate between aspects of memory (semantic, episodic, and working) versus attention. Sleepiness was measured on the basis of the Epworth Sleepiness Scale and Oxford Sleep Resistance test. Memory performance in patients versus control subjects was compared (Mann-Whitney U test; P < 0.01, Bonferroni corrected for multiple comparisons) and relationships between performance and disease severity were analyzed by linear regression.
Sixty patients and healthy control subjects matched for age (mean +/- SD: patients, 51 +/- 9 yr; control subjects, 50 +/- 9 yr) and education (patients, 14 +/- 3 yr; control subjects, 15 +/- 3 yr) participated. Patients demonstrated impaired Logical Memory Test results (immediate recall: patients, median [range], 36 [9-69]; control subjects, 43 [19-64], P = 0.0004; and delayed recall: patients, 22 [6-42]; control subjects, 27 [10-46]; P = 0.0001). There were minimal differences in attention, visual episodic, semantic, or working memory; patients performed better than control subjects on Spatial Span forward and backward. Regression analysis revealed that Logical Memory Test performance was not significantly related to disease severity after controlling for age, education, and sleepiness.
Obstructive sleep apnea is associated with impairment in verbal, but not visual, memory. The impairment was present across a range of disease severity and was not explained by reduced attention. Such verbal memory impairment may affect daytime functioning and performance.</abstract><cop>New York, NY</cop><pub>American Thoracic Society</pub><pmid>20299536</pmid><doi>10.1164/rccm.200901-0065OC</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2010-07, Vol.182 (1), p.98-103 |
| issn | 1073-449X 1535-4970 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; Alma/SFX Local Collection |
| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Case-Control Studies Chronic obstructive pulmonary disease, asthma Cognitive ability Female G. Sleep and Control of Ventilation Health care Humans Hypotheses Intensive care medicine Male Mann-Whitney U test Medical sciences Memory Memory Disorders - etiology Mental Recall Patients Pattern Recognition, Visual Pneumology Polysomnography Regression analysis Semantics Sleep apnea Sleep Apnea, Obstructive - complications Verbal Learning |
| title | Obstructive Sleep Apnea Syndrome Is Associated with Deficits in Verbal but Not Visual Memory |
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