Computational analysis of human adenovirus serotype 18
Abstract The genome of the sole remaining unsequenced member of species A, human adenovirus type 18 (HAdV-A18), has been sequenced and analyzed. Members of species A are implicated as gastrointestinal pathogens and were shown to be tumorigenic in rodents. These whole genome and in silico proteome da...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2010-09, Vol.404 (2), p.284-292 |
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| creator | Walsh, Michael P Seto, Jason Tirado, Damaris Chodosh, James Schnurr, David Seto, Donald Jones, Morris S |
| description | Abstract The genome of the sole remaining unsequenced member of species A, human adenovirus type 18 (HAdV-A18), has been sequenced and analyzed. Members of species A are implicated as gastrointestinal pathogens and were shown to be tumorigenic in rodents. These whole genome and in silico proteome data are important as references for reexamining and integrating earlier work and observations based on lower resolution techniques, such as restriction enzyme digestion patterns, particularly for hypotheses based on pre-genomics data. Additionally, the genome of HAdV-A18 will also serve as reference for current studies examining the molecular evolution and origins of human and simian adenoviruses, particularly genome recombination studies. Applications of this virus as a potential vector for gene delivery protocols may be practical as data accumulate on this and other adenovirus genomes. |
| doi_str_mv | 10.1016/j.virol.2010.05.013 |
| format | Article |
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Members of species A are implicated as gastrointestinal pathogens and were shown to be tumorigenic in rodents. These whole genome and in silico proteome data are important as references for reexamining and integrating earlier work and observations based on lower resolution techniques, such as restriction enzyme digestion patterns, particularly for hypotheses based on pre-genomics data. Additionally, the genome of HAdV-A18 will also serve as reference for current studies examining the molecular evolution and origins of human and simian adenoviruses, particularly genome recombination studies. 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All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-fed90b03ed2ec0f230604242533202135aded9c44f99578aa1e5b58fe59c09133</citedby><cites>FETCH-LOGICAL-c611t-fed90b03ed2ec0f230604242533202135aded9c44f99578aa1e5b58fe59c09133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.virol.2010.05.013$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,315,782,786,887,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20542532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walsh, Michael P</creatorcontrib><creatorcontrib>Seto, Jason</creatorcontrib><creatorcontrib>Tirado, Damaris</creatorcontrib><creatorcontrib>Chodosh, James</creatorcontrib><creatorcontrib>Schnurr, David</creatorcontrib><creatorcontrib>Seto, Donald</creatorcontrib><creatorcontrib>Jones, Morris S</creatorcontrib><title>Computational analysis of human adenovirus serotype 18</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>Abstract The genome of the sole remaining unsequenced member of species A, human adenovirus type 18 (HAdV-A18), has been sequenced and analyzed. 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Applications of this virus as a potential vector for gene delivery protocols may be practical as data accumulate on this and other adenovirus genomes.</description><subject>Adenovirus</subject><subject>Adenoviruses, Human - classification</subject><subject>Adenoviruses, Human - genetics</subject><subject>Base Sequence</subject><subject>Computational Biology</subject><subject>DNA, Viral - genetics</subject><subject>Gene Expression Regulation, Viral</subject><subject>Genome, Viral</subject><subject>Human adenovirus</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Molecular evolution</subject><subject>Molecular Sequence Data</subject><subject>Nucleic Acid Hybridization - methods</subject><subject>Oncogenesis</subject><subject>Phylogeny</subject><subject>Proteome - chemistry</subject><subject>RNA, Viral - chemistry</subject><subject>Serotyping</subject><subject>Species A</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsFu1DAQtRCILoUvQEK5ccp2bMfe-EAltCpQqVIPtBK3kdeZUC9JvNjJSvv3ON1SQS-92PL4zXsz84ax9xyWHLg-2y73PoZuKSBHQC2ByxdswcHoEmTFX7IFQCVKXQtxwt6ktIX8Xq3gNTsRoCqhpFgwvQ79bhrt6MNgu8Lm45B8KkJb3E29HQrb0BCy0JSKRDGMhx0VvH7LXrW2S_Tu4T5lt18ubtbfyqvrr5frz1el05yPZUuNgQ1IagQ5aIUEnUuapaUAwaXK7I1xVdUao1a1tZzURtUtKePAcClP2fmRdzdtemocDWO0He6i7208YLAe__8Z_B3-DHsUBoSuVSb4-EAQw--J0oi9T466zg4UpoQrVSkt82SeR0qpTK1rnpHyiHQxpBSpfayHA87W4BbvrcHZGgSFcN_Kh39becz560UGfDoCKA907ylicp4GR42P5EZsgn9G4PxJvuv84J3tftGB0jZMMbubkGMSCPh93o55Ofjcvax-yD8bQrVx</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Walsh, Michael P</creator><creator>Seto, Jason</creator><creator>Tirado, Damaris</creator><creator>Chodosh, James</creator><creator>Schnurr, David</creator><creator>Seto, Donald</creator><creator>Jones, Morris S</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20100901</creationdate><title>Computational analysis of human adenovirus serotype 18</title><author>Walsh, Michael P ; 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Adenovirus Adenoviruses, Human - classification Adenoviruses, Human - genetics Base Sequence Computational Biology DNA, Viral - genetics Gene Expression Regulation, Viral Genome, Viral Human adenovirus Humans Infectious Disease Molecular evolution Molecular Sequence Data Nucleic Acid Hybridization - methods Oncogenesis Phylogeny Proteome - chemistry RNA, Viral - chemistry Serotyping Species A |
| title | Computational analysis of human adenovirus serotype 18 |
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