Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators

To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly)...

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Veröffentlicht in:	Blood 2010-07, Vol.115 (26), p.5289-5299
Hauptverfasser:	Schnabel, Renate B., Baumert, Jens, Barbalic, Maja, Dupuis, Josée, Ellinor, Patrick T., Durda, Peter, Dehghan, Abbas, Bis, Joshua C., Illig, Thomas, Morrison, Alanna C., Jenny, Nancy S., Keaney, John F., Gieger, Christian, Tilley, Cathy, Yamamoto, Jennifer F., Khuseyinova, Natalie, Heiss, Gerardo, Doyle, Margaret, Blankenberg, Stefan, Herder, Christian, Walston, Jeremy D., Zhu, Yanyan, Vasan, Ramachandran S., Klopp, Norman, Boerwinkle, Eric, Larson, Martin G., Psaty, Bruce M., Peters, Annette, Ballantyne, Christie M., Witteman, Jacqueline C.M., Hoogeveen, Ron C., Benjamin, Emelia J., Koenig, Wolfgang, Tracy, Russell P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Chemokine CCL2 - blood Chemokine CCL2 - genetics Chromosomes, Human, Pair 1 Cohort Studies Duffy Blood-Group System - genetics Duffy Blood-Group System - metabolism Erythrocytes - metabolism Female Genetic Loci Genome-Wide Association Study Hematologic and hematopoietic diseases Humans Inflammation Mediators - blood Male Medical sciences Middle Aged Plenary Paper Polymorphism, Single Nucleotide Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism
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