Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

RATIONALE:Superoxide ( ) has been implicated in the pathogenesis of many human diseases including hypertension; however, commonly used antioxidants have proven ineffective in clinical trials. It is possible that these agents are not adequately delivered to the subcellular sites of superoxide product...

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Veröffentlicht in:	Circulation research 2010-07, Vol.107 (1), p.106-116
Hauptverfasser:	Dikalova, Anna E, Bikineyeva, Alfiya T, Budzyn, Klaudia, Nazarewicz, Rafal R, McCann, Louise, Lewis, William, Harrison, David G, Dikalov, Sergey I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - administration & dosage Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cattle Cells, Cultured Cyclic N-Oxides - administration & dosage Drug Delivery Systems - methods Endothelial Cells Fundamental and applied biological sciences. Psychology Humans Hypertension - drug therapy Hypertension - enzymology Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Mitochondria - drug effects Mitochondria - enzymology Superoxide Dismutase - biosynthesis Superoxides - metabolism Vertebrates: cardiovascular system
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