Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line

We previously reported that a single DNA double-strand break (DSB) near a telomere in mouse embryonic stem cells can result in chromosome instability. We have observed this same type of instability as a result of spontaneous telomere loss in human tumor cell lines, suggesting that a deficiency in th...

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Veröffentlicht in:	DNA repair 2009-08, Vol.8 (8), p.886-900
Hauptverfasser:	Zschenker, Oliver, Kulkarni, Avanti, Miller, Douglas, Reynolds, Gloria. E., Granger-Locatelli, Marine, Pottier, Géraldine, Sabatier, Laure, Murnane, John. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Base Sequence Biological and medical sciences Blotting, Southern Cell Line, Tumor Chromosomal instability Chromosomal Instability - drug effects Chromosomes, Human - genetics Clone Cells Deoxyribonucleases, Type II Site-Specific - metabolism DNA Breaks, Double-Stranded - drug effects Double-strand break Fundamental and applied biological sciences. Psychology Ganciclovir - pharmacology Gene Rearrangement - drug effects Gene Silencing - drug effects Gross chromosomal rearrangements Growth, nutrition, cell differenciation Humans Microbiology Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutagenesis. Repair Plasmids - genetics Polymerase Chain Reaction Recombination, Genetic - drug effects Sequence Deletion - drug effects Simplexvirus - enzymology Sister chromatid fusion Telomere - metabolism Telomeres Thymidine Kinase - genetics
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