mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1

Synthesis of tRNA and 5S rRNA by RNA polymerase (pol) III is regulated by the mTOR pathway in mammalian cells. The mTOR kinase localizes to tRNA and 5S rRNA genes, providing an opportunity for direct control. Its presence at these sites can be explained by interaction with TFIIIC, a DNA-binding fact...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-06, Vol.107 (26), p.11823-11828
Hauptverfasser:	Kantidakis, Theodoros, Ramsbottom, Ben A., Birch, Joanna L., Dowding, Sarah N., White, Robert J., Hahn, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Base Sequence Binding Sites Biological Sciences Birds of prey Cell lines Cells Chromatin Immunoprecipitation Genes HeLa Cells Humans Intracellular Signaling Peptides and Proteins - metabolism Kinases Mutagenesis, Site-Directed Phosphorylation Protein-Serine-Threonine Kinases - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism RNA RNA polymerase RNA Polymerase III - metabolism RNA, Ribosomal, 5S - genetics RNA, Ribosomal, 5S - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism rRNA genes Serine - chemistry Signal transduction TOR Serine-Threonine Kinases Transcription Factors, TFIII - metabolism Transfer RNA Yeast Yeasts
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