MPTP treatment increases expression of pre-pro-nociceptin/orphanin FQ mRNA in a subset of substantia nigra reticulata neurons

Abstract Antagonists selectively inhibiting activation of the nociceptin/orphanin FQ (N/OFQ) receptor reduce motor symptoms in experimental models of Parkinson's disease, and genetic deletion of the ppN/OFQ gene offers partial protection of mid-brain dopamine neurons against the neurotoxin, 1-m...

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Veröffentlicht in:	Neuroscience 2010-08, Vol.169 (1), p.269-278
Hauptverfasser:	Gouty, S, Brown, J.M, Rosenberger, J, Cox, B.M
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Animal models Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases dopamine Fundamental and applied biological sciences. Psychology GABA Gene Expression Regulation - drug effects Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout MPTP Poisoning - genetics Neurology Neurons - classification Neurons - drug effects Neurons - metabolism Nociceptin Opioid Peptides - biosynthesis Opioid Peptides - genetics orphanin FQ Parkinson's disease Parkinsonian Disorders - genetics Protein Precursors - biosynthesis Protein Precursors - deficiency Protein Precursors - genetics Receptors, Opioid - biosynthesis Receptors, Opioid - deficiency Receptors, Opioid - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Substantia Nigra - drug effects Substantia Nigra - metabolism Ventral Tegmental Area - drug effects Ventral Tegmental Area - metabolism Vertebrates: nervous system and sense organs
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