Dietary intake of pterostilbene, a constituent of blueberries, inhibits the β-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats

Stilbenes are phytochemicals present in grapes, berries, peanuts and red wine. A widely studied stilbene, resveratrol (trans-3,5,4′-trihydroxystilbene), has been shown to exert antioxidant, anti-inflammatory, chemopreventive and antiaging effects in a number of biological systems. We reported earlie...

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Veröffentlicht in:	Carcinogenesis (New York) 2010-07, Vol.31 (7), p.1272-1278
Hauptverfasser:	Paul, Shiby, DeCastro, Andrew J, Lee, Hong Jin, Smolarek, Amanda K, So, Jae Young, Simi, Barbara, Wang, Chung Xiou, Zhou, Renping, Rimando, Agnes M, Suh, Nanjoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticarcinogenic activity Azoxymethane beta Catenin - analysis beta Catenin - antagonists & inhibitors beta Catenin - physiology Biological and medical sciences blueberries breeding sites Cancer Prevention carcinogenesis Carcinogenesis, carcinogens and anticarcinogens cell proliferation Chemical agents colon Colonic Neoplasms - prevention & control colorectal neoplasms Cyclin D1 - analysis Cyclooxygenase 2 - analysis Cytokines - analysis Cytokines - antagonists & inhibitors Gastroenterology. Liver. Pancreas. Abdomen gene expression regulation HT29 Cells Humans interleukin-1 interleukin-4 intestinal mucosa Male Medical sciences Nitric Oxide Synthase Type II - analysis Phosphorylation proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - analysis protein phosphorylation Proto-Oncogene Proteins c-myc - analysis Rats Rats, Inbred F344 resveratrol Signal Transduction - drug effects Stilbenes - administration & dosage Stomach. Duodenum. Small intestine. Colon. Rectum. Anus subcutaneous injection Transcription Factor RelA - antagonists & inhibitors Transcription Factor RelA - physiology tumor necrosis factor-alpha Tumors
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