Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges
Lumbar discectomy is a very effective therapy for neurological decompression in patients suffering from sciatica due to hernia nuclei pulposus. However, high recurrence rates and persisting post-operative low back pain in these patients require serious attention. In the past decade, tissue engineeri...
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| Veröffentlicht in: | European spine journal 2009-03, Vol.18 (3), p.301-313 |
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| creator | Bron, Johannes Leendert Helder, Marco N. Meisel, Hans-Jorg Van Royen, Barend J. Smit, Theodoor H. |
| description | Lumbar discectomy is a very effective therapy for neurological decompression in patients suffering from sciatica due to hernia nuclei pulposus. However, high recurrence rates and persisting post-operative low back pain in these patients require serious attention. In the past decade, tissue engineering strategies have been developed mainly targeted to the regeneration of the nucleus pulposus (NP) of the intervertebral disc. Accompanying techniques that deal with the damaged annulus fibrous are now increasingly recognised as mandatory in order to prevent re-herniation to increase the potential of NP repair and to confine NP replacement therapies. In the current review, the requirements, achievements and challenges in this quickly emerging field of research are discussed. |
| doi_str_mv | 10.1007/s00586-008-0856-x |
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However, high recurrence rates and persisting post-operative low back pain in these patients require serious attention. In the past decade, tissue engineering strategies have been developed mainly targeted to the regeneration of the nucleus pulposus (NP) of the intervertebral disc. Accompanying techniques that deal with the damaged annulus fibrous are now increasingly recognised as mandatory in order to prevent re-herniation to increase the potential of NP repair and to confine NP replacement therapies. 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In the current review, the requirements, achievements and challenges in this quickly emerging field of research are discussed.</description><subject>Animals</subject><subject>Diskectomy - methods</subject><subject>Fibrocartilage - pathology</subject><subject>Fibrocartilage - physiopathology</subject><subject>Fibrocartilage - surgery</subject><subject>Guided Tissue Regeneration - methods</subject><subject>Guided Tissue Regeneration - trends</subject><subject>Humans</subject><subject>Intervertebral Disc - pathology</subject><subject>Intervertebral Disc - physiopathology</subject><subject>Intervertebral Disc - surgery</subject><subject>Intervertebral Disc Displacement - pathology</subject><subject>Intervertebral Disc Displacement - physiopathology</subject><subject>Intervertebral Disc Displacement - surgery</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Lumbar Vertebrae - physiopathology</subject><subject>Lumbar Vertebrae - surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Pain, Postoperative - etiology</subject><subject>Pain, Postoperative - physiopathology</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Review</subject><subject>Secondary Prevention</subject><subject>Surgical Orthopedics</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Engineering - trends</subject><issn>0940-6719</issn><issn>1432-0932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFUV1LHDEUDUWpW9sf0BcZfOiTozfJJJP4IBSxKghCaZ9DJnNnNzI7MyYzy_bfN-su2griU7icj5x7DyFfKZxSgPIsAgglcwCVgxIyX38gM1pwloPmbI_MQBeQy5LqA_IpxgcAKjTIj-SAagqFEjAj1U8crA8nWcA5dhjs6FeY2a7O4jQMfXgax0UCBo8x65vNkPBuaqeYNb4KfZzieWbdwuMKl9iN8UnuFrZtsZtj_Ez2G9tG_LJ7D8nvH1e_Lm_yu_vr28vvd7kTshhz4RpXilqpytmqplw2teSsZDTBnLLSUd1ggSWXjpWIvBZp91qKgiqmrRD8kFxsfYepWmLtUpRgWzMEv7Thj-mtN_8jnV-Yeb8yTGldMJ4Mvu0MQv84YRzN0keHbWs77KdopNRKMq7eJTIQVHAGiXj8ivjQT6FLVzCMQyEF45vcdEty6ZYxYPMcmYLZ9Gy2PZvUs9n0bNZJc_Tvri-KXbGJwLaEmKDUQnj5-W3Xv5vQtYM</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Bron, Johannes Leendert</creator><creator>Helder, Marco N.</creator><creator>Meisel, Hans-Jorg</creator><creator>Van Royen, Barend J.</creator><creator>Smit, Theodoor H.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090301</creationdate><title>Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges</title><author>Bron, Johannes Leendert ; 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Animals Diskectomy - methods Fibrocartilage - pathology Fibrocartilage - physiopathology Fibrocartilage - surgery Guided Tissue Regeneration - methods Guided Tissue Regeneration - trends Humans Intervertebral Disc - pathology Intervertebral Disc - physiopathology Intervertebral Disc - surgery Intervertebral Disc Displacement - pathology Intervertebral Disc Displacement - physiopathology Intervertebral Disc Displacement - surgery Lumbar Vertebrae - pathology Lumbar Vertebrae - physiopathology Lumbar Vertebrae - surgery Medicine Medicine & Public Health Neurosurgery Pain, Postoperative - etiology Pain, Postoperative - physiopathology Pain, Postoperative - prevention & control Review Secondary Prevention Surgical Orthopedics Tissue Engineering - methods Tissue Engineering - trends |
| title | Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges |
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