Homocysteine and markers of inflammation in acute coronary syndrome
An elevated level of homocysteine (Hcy) has been shown to be a cardiovascular risk factor in the majority of research studies. Recently, it was found to be associated with new risk factors such as inflammatory markers. To investigate the distribution of plasma total Hcy (tHcy) and the levels of infl...
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| Veröffentlicht in: | Experimental and clinical cardiology 2010-01, Vol.15 (2), p.e25-e28 |
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| container_title | Experimental and clinical cardiology |
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| creator | Oudi, Mabrouka El Aouni, Zied Mazigh, Chakib Khochkar, Radhia Gazoueni, Ezzeddine Haouela, Habib Machghoul, Salem |
| description | An elevated level of homocysteine (Hcy) has been shown to be a cardiovascular risk factor in the majority of research studies. Recently, it was found to be associated with new risk factors such as inflammatory markers.
To investigate the distribution of plasma total Hcy (tHcy) and the levels of inflammatory markers in patients with acute coronary syndrome (ACS), and to evaluate the association between these parameters and the severity of the disease.
A total of 122 patients with ACS and 80 control subjects were recruited from the cardiac intensive care unit of the Military Hospital of Tunis, Tunisia. Lipid profile and the levels of tHcy, high-sensitivity C-reactive protein (HsCRP), interleukin (IL)-6, IL-8, IL-1beta and tumour necrosis factor-alpha (TNFalpha) were determined for all participants. The distribution of these parameters were compared between groups and according to the number of diseased vessels in patients with ACS.
ACS patients had significantly elevated levels of tHcy (P |
| format | Article |
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To investigate the distribution of plasma total Hcy (tHcy) and the levels of inflammatory markers in patients with acute coronary syndrome (ACS), and to evaluate the association between these parameters and the severity of the disease.
A total of 122 patients with ACS and 80 control subjects were recruited from the cardiac intensive care unit of the Military Hospital of Tunis, Tunisia. Lipid profile and the levels of tHcy, high-sensitivity C-reactive protein (HsCRP), interleukin (IL)-6, IL-8, IL-1beta and tumour necrosis factor-alpha (TNFalpha) were determined for all participants. The distribution of these parameters were compared between groups and according to the number of diseased vessels in patients with ACS.
ACS patients had significantly elevated levels of tHcy (P<0.01), HsCRP (P<0.001), IL-6 (P<0.001), TNFalpha (P<0.001), folates (P<0.05) and vitamin B(12) (P<0.001), but lower high-density lipoprotein cholesterol (P<0.05) levels. The analysis of the association between these parameters and the number of diseased vessels showed significant differences in tHcy, HsCRP, IL-6 and TNFalpha, with positive correlations. Significantly negative correlations were found between the number of diseased vessels and folate (r=-0.34; P<0.01), and vitamin B(12) (r=-0.22; P<0.01).
Elevated levels of tHcy, IL-6, TNFalpha and HsCRP appear to be associated with a greater number of diseased arteries and, consequently, the severity of coronary artery disease.]]></description><identifier>ISSN: 1205-6626</identifier><identifier>EISSN: 1918-1515</identifier><identifier>PMID: 20631860</identifier><language>eng</language><publisher>Canada: Pulsus Group Inc</publisher><subject>Clinical Cardiology: Original</subject><ispartof>Experimental and clinical cardiology, 2010-01, Vol.15 (2), p.e25-e28</ispartof><rights>2010, Pulsus Group Inc. All rights reserved</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898531/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898531/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20631860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oudi, Mabrouka El</creatorcontrib><creatorcontrib>Aouni, Zied</creatorcontrib><creatorcontrib>Mazigh, Chakib</creatorcontrib><creatorcontrib>Khochkar, Radhia</creatorcontrib><creatorcontrib>Gazoueni, Ezzeddine</creatorcontrib><creatorcontrib>Haouela, Habib</creatorcontrib><creatorcontrib>Machghoul, Salem</creatorcontrib><title>Homocysteine and markers of inflammation in acute coronary syndrome</title><title>Experimental and clinical cardiology</title><addtitle>Exp Clin Cardiol</addtitle><description><![CDATA[An elevated level of homocysteine (Hcy) has been shown to be a cardiovascular risk factor in the majority of research studies. Recently, it was found to be associated with new risk factors such as inflammatory markers.
To investigate the distribution of plasma total Hcy (tHcy) and the levels of inflammatory markers in patients with acute coronary syndrome (ACS), and to evaluate the association between these parameters and the severity of the disease.
A total of 122 patients with ACS and 80 control subjects were recruited from the cardiac intensive care unit of the Military Hospital of Tunis, Tunisia. Lipid profile and the levels of tHcy, high-sensitivity C-reactive protein (HsCRP), interleukin (IL)-6, IL-8, IL-1beta and tumour necrosis factor-alpha (TNFalpha) were determined for all participants. The distribution of these parameters were compared between groups and according to the number of diseased vessels in patients with ACS.
ACS patients had significantly elevated levels of tHcy (P<0.01), HsCRP (P<0.001), IL-6 (P<0.001), TNFalpha (P<0.001), folates (P<0.05) and vitamin B(12) (P<0.001), but lower high-density lipoprotein cholesterol (P<0.05) levels. The analysis of the association between these parameters and the number of diseased vessels showed significant differences in tHcy, HsCRP, IL-6 and TNFalpha, with positive correlations. Significantly negative correlations were found between the number of diseased vessels and folate (r=-0.34; P<0.01), and vitamin B(12) (r=-0.22; P<0.01).
Elevated levels of tHcy, IL-6, TNFalpha and HsCRP appear to be associated with a greater number of diseased arteries and, consequently, the severity of coronary artery disease.]]></description><subject>Clinical Cardiology: Original</subject><issn>1205-6626</issn><issn>1918-1515</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNpVkNtKxDAQhoMo7rr6CpIXKOTQpOmNIIu6Cwve6HWZ5qDRJilJV-jbW_CAXs0MP__Hx5ygNW2pqqig4nTZGRGVlEyu0EUpb4TUtGnlOVoxIjlVkqzRdpdC0nOZrI8WQzQ4QH63ueDksI9ugBBg8ikuBwZ9nCzWKacIecZljianYC_RmYOh2KvvuUHP93dP2111eHzYb28P1UglnyqnVe_6RvY1aYi2SpFWC8IVU0bYRVLzljndguqlcwaUMsBqoY3VXOqm4XyDbr6447EP1mgbpwxDN2a_OM9dAt_9T6J_7V7SR8dUqwSnC-D6L-C3-fMO_gmSQl-x</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Oudi, Mabrouka El</creator><creator>Aouni, Zied</creator><creator>Mazigh, Chakib</creator><creator>Khochkar, Radhia</creator><creator>Gazoueni, Ezzeddine</creator><creator>Haouela, Habib</creator><creator>Machghoul, Salem</creator><general>Pulsus Group Inc</general><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>20100101</creationdate><title>Homocysteine and markers of inflammation in acute coronary syndrome</title><author>Oudi, Mabrouka El ; Aouni, Zied ; Mazigh, Chakib ; Khochkar, Radhia ; Gazoueni, Ezzeddine ; Haouela, Habib ; Machghoul, Salem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p163t-fc8bfb76b4070ce8809c503828d5e626c392fc9a8b6ffda88da245cdec36c7733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Clinical Cardiology: Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oudi, Mabrouka El</creatorcontrib><creatorcontrib>Aouni, Zied</creatorcontrib><creatorcontrib>Mazigh, Chakib</creatorcontrib><creatorcontrib>Khochkar, Radhia</creatorcontrib><creatorcontrib>Gazoueni, Ezzeddine</creatorcontrib><creatorcontrib>Haouela, Habib</creatorcontrib><creatorcontrib>Machghoul, Salem</creatorcontrib><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental and clinical cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oudi, Mabrouka El</au><au>Aouni, Zied</au><au>Mazigh, Chakib</au><au>Khochkar, Radhia</au><au>Gazoueni, Ezzeddine</au><au>Haouela, Habib</au><au>Machghoul, Salem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homocysteine and markers of inflammation in acute coronary syndrome</atitle><jtitle>Experimental and clinical cardiology</jtitle><addtitle>Exp Clin Cardiol</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>15</volume><issue>2</issue><spage>e25</spage><epage>e28</epage><pages>e25-e28</pages><issn>1205-6626</issn><eissn>1918-1515</eissn><abstract><![CDATA[An elevated level of homocysteine (Hcy) has been shown to be a cardiovascular risk factor in the majority of research studies. Recently, it was found to be associated with new risk factors such as inflammatory markers.
To investigate the distribution of plasma total Hcy (tHcy) and the levels of inflammatory markers in patients with acute coronary syndrome (ACS), and to evaluate the association between these parameters and the severity of the disease.
A total of 122 patients with ACS and 80 control subjects were recruited from the cardiac intensive care unit of the Military Hospital of Tunis, Tunisia. Lipid profile and the levels of tHcy, high-sensitivity C-reactive protein (HsCRP), interleukin (IL)-6, IL-8, IL-1beta and tumour necrosis factor-alpha (TNFalpha) were determined for all participants. The distribution of these parameters were compared between groups and according to the number of diseased vessels in patients with ACS.
ACS patients had significantly elevated levels of tHcy (P<0.01), HsCRP (P<0.001), IL-6 (P<0.001), TNFalpha (P<0.001), folates (P<0.05) and vitamin B(12) (P<0.001), but lower high-density lipoprotein cholesterol (P<0.05) levels. The analysis of the association between these parameters and the number of diseased vessels showed significant differences in tHcy, HsCRP, IL-6 and TNFalpha, with positive correlations. Significantly negative correlations were found between the number of diseased vessels and folate (r=-0.34; P<0.01), and vitamin B(12) (r=-0.22; P<0.01).
Elevated levels of tHcy, IL-6, TNFalpha and HsCRP appear to be associated with a greater number of diseased arteries and, consequently, the severity of coronary artery disease.]]></abstract><cop>Canada</cop><pub>Pulsus Group Inc</pub><pmid>20631860</pmid></addata></record> |
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| ispartof | Experimental and clinical cardiology, 2010-01, Vol.15 (2), p.e25-e28 |
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| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Clinical Cardiology: Original |
| title | Homocysteine and markers of inflammation in acute coronary syndrome |
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