Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

Clinically relevant biomarkers for predicting the outcome of treatment in patients with Hodgkin's disease have not been established. In this study, gene profiling and immunohistochemical analysis were used to find such a marker. A strong association was found between a poor outcome of treatment...

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Veröffentlicht in:	The New England journal of medicine 2010-03, Vol.362 (10), p.875-885
Hauptverfasser:	Steidl, Christian, Lee, Tang, Shah, Sohrab P, Farinha, Pedro, Han, Guangming, Nayar, Tarun, Delaney, Allen, Jones, Steven J, Iqbal, Javeed, Weisenburger, Dennis D, Bast, Martin A, Rosenwald, Andreas, Muller-Hermelink, Hans-Konrad, Rimsza, Lisa M, Campo, Elias, Delabie, Jan, Braziel, Rita M, Cook, James R, Tubbs, Ray R, Jaffe, Elaine S, Lenz, Georg, Connors, Joseph M, Staudt, Louis M, Chan, Wing C, Gascoyne, Randy D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Analysis of Variance Antigens, CD - analysis Antigens, Differentiation, Myelomonocytic - analysis Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Child Disease-Free Survival Female Gene Expression Gene Expression Profiling Gene Expression Regulation, Neoplastic General aspects Hematologic and hematopoietic diseases Hodgkin Disease - genetics Hodgkin Disease - mortality Hodgkin Disease - pathology Humans Immunohistochemistry Kaplan-Meier Estimate Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Lymphoma Macrophages - immunology Male Medical research Medical sciences Middle Aged Neoplasm Staging Prognosis Reed-Sternberg Cells - pathology RNA, Neoplasm - analysis Success Survival Rate Treatment Failure Young Adult
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