Conserved Discrimination against Misacylated tRNAs by Two Mesophilic Elongation Factor Tu Orthologs

Elongation factor Tu (EF-Tu) binds and loads elongating aminoacyl-tRNAs (aa-tRNAs) onto the ribosome for protein biosynthesis. Many bacteria biosynthesize Gln-tRNAGln and Asn-tRNAAsn by an indirect, two-step pathway that relies on the misacylated tRNAs Glu-tRNAGln and Asp-tRNAAsn as intermediates. P...

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Veröffentlicht in:	Biochemistry (Easton) 2008-07, Vol.47 (29), p.7610-7616
Hauptverfasser:	Cathopoulis, Terry J. T, Chuawong, Pitak, Hendrickson, Tamara L
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Escherichia coli - genetics Escherichia coli - metabolism Gene Expression Regulation, Bacterial Helicobacter pylori - genetics Helicobacter pylori - metabolism Hydrolysis Kinetics Peptide Elongation Factor Tu - chemistry Peptide Elongation Factor Tu - genetics Peptide Elongation Factor Tu - metabolism RNA, Transfer, Amino Acyl - chemistry RNA, Transfer, Amino Acyl - genetics RNA, Transfer, Amino Acyl - metabolism RNA, Transfer, Asn - chemistry RNA, Transfer, Asn - metabolism
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