Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice
The aims of the present paper were to ascertain whether the heat-induced ischemia and oxidative damage to the hypothalamus and lethality in mice could be ameliorated by hyperbaric oxygen therapy. When normobaric air-treated mice underwent heat treatment, the fractional survival and core temperature...
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| Veröffentlicht in: | BioMed research international 2010-01, Vol.2010 (2010), p.1-11 |
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| creator | Tai, Po-An Chang, Chen-Kuei Niu, Ko-Chi Lin, Mao- Tsun Chiu, Wen-Ta Lin, Jia-Wei |
| description | The aims of the present paper were to ascertain whether the heat-induced ischemia and oxidative damage to the hypothalamus and lethality in mice could be ameliorated by hyperbaric oxygen therapy. When normobaric air-treated mice underwent heat treatment, the fractional survival and core temperature at 4 hours after heat stress were found to be 0 of 12 and 34∘C±0.3∘C, respectively. In hyperbaric oxygen-treated mice, when exposed to the same treatment, both fractional survival and core temperature values were significantly increased to new values of 12/12 and 37.3∘C±0.3∘C, respectively. Compared to normobaric air-treated heatstroke mice, hyperbaric oxygen-treated mice displayed lower hypothalamic values of cellular ischemia and damage markers, prooxidant enzymes, proinflammatory cytokines, inducible nitric oxide synthase-dependent nitric oxide, and neuronal damage score. The data indicate that hyperbaric oxygen may improve outcomes of heatstroke by normalization of hypothalamic and thermoregulatory function in mice. |
| doi_str_mv | 10.1155/2010/609526 |
| format | Article |
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When normobaric air-treated mice underwent heat treatment, the fractional survival and core temperature at 4 hours after heat stress were found to be 0 of 12 and 34∘C±0.3∘C, respectively. In hyperbaric oxygen-treated mice, when exposed to the same treatment, both fractional survival and core temperature values were significantly increased to new values of 12/12 and 37.3∘C±0.3∘C, respectively. Compared to normobaric air-treated heatstroke mice, hyperbaric oxygen-treated mice displayed lower hypothalamic values of cellular ischemia and damage markers, prooxidant enzymes, proinflammatory cytokines, inducible nitric oxide synthase-dependent nitric oxide, and neuronal damage score. The data indicate that hyperbaric oxygen may improve outcomes of heatstroke by normalization of hypothalamic and thermoregulatory function in mice.</description><identifier>ISSN: 1110-7243</identifier><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 1110-7251</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2010/609526</identifier><identifier>PMID: 20625500</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Animals ; Biological and medical sciences ; Biomedical research ; Brain Ischemia - enzymology ; Brain Ischemia - etiology ; Brain Ischemia - pathology ; Brain Ischemia - therapy ; Cytokines - metabolism ; Extracellular Space - metabolism ; Heat Stroke - complications ; Heat Stroke - pathology ; Heat Stroke - therapy ; Heatstroke ; Hyperbaric Oxygenation ; Hypothalamus - enzymology ; Hypothalamus - pathology ; Inflammation Mediators - metabolism ; Male ; Medical research ; Medical sciences ; Mice ; Mice, Inbred ICR ; Mortality ; Neurons - metabolism ; Neurons - pathology ; Nitric Oxide Synthase Type II - metabolism ; Oxidative Stress ; Pharmacology. Drug treatments ; Proteins ; Rodents ; Survival Analysis</subject><ispartof>BioMed research international, 2010-01, Vol.2010 (2010), p.1-11</ispartof><rights>Copyright © 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Po-An Tai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2010 Po-An Tai et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-5c609984705d2021091e4e742378c5b38b483c5127213b585ce24813152ae0c73</citedby><cites>FETCH-LOGICAL-c526t-5c609984705d2021091e4e742378c5b38b483c5127213b585ce24813152ae0c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896702/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896702/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25876445$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20625500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Griffith, Thomas</contributor><creatorcontrib>Tai, Po-An</creatorcontrib><creatorcontrib>Chang, Chen-Kuei</creatorcontrib><creatorcontrib>Niu, Ko-Chi</creatorcontrib><creatorcontrib>Lin, Mao- Tsun</creatorcontrib><creatorcontrib>Chiu, Wen-Ta</creatorcontrib><creatorcontrib>Lin, Jia-Wei</creatorcontrib><title>Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice</title><title>BioMed research international</title><addtitle>J Biomed Biotechnol</addtitle><description>The aims of the present paper were to ascertain whether the heat-induced ischemia and oxidative damage to the hypothalamus and lethality in mice could be ameliorated by hyperbaric oxygen therapy. When normobaric air-treated mice underwent heat treatment, the fractional survival and core temperature at 4 hours after heat stress were found to be 0 of 12 and 34∘C±0.3∘C, respectively. In hyperbaric oxygen-treated mice, when exposed to the same treatment, both fractional survival and core temperature values were significantly increased to new values of 12/12 and 37.3∘C±0.3∘C, respectively. Compared to normobaric air-treated heatstroke mice, hyperbaric oxygen-treated mice displayed lower hypothalamic values of cellular ischemia and damage markers, prooxidant enzymes, proinflammatory cytokines, inducible nitric oxide synthase-dependent nitric oxide, and neuronal damage score. The data indicate that hyperbaric oxygen may improve outcomes of heatstroke by normalization of hypothalamic and thermoregulatory function in mice.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical research</subject><subject>Brain Ischemia - enzymology</subject><subject>Brain Ischemia - etiology</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - therapy</subject><subject>Cytokines - metabolism</subject><subject>Extracellular Space - metabolism</subject><subject>Heat Stroke - complications</subject><subject>Heat Stroke - pathology</subject><subject>Heat Stroke - therapy</subject><subject>Heatstroke</subject><subject>Hyperbaric Oxygenation</subject><subject>Hypothalamus - enzymology</subject><subject>Hypothalamus - pathology</subject><subject>Inflammation Mediators - metabolism</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Mortality</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Oxidative Stress</subject><subject>Pharmacology. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tai, Po-An</au><au>Chang, Chen-Kuei</au><au>Niu, Ko-Chi</au><au>Lin, Mao- Tsun</au><au>Chiu, Wen-Ta</au><au>Lin, Jia-Wei</au><au>Griffith, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice</atitle><jtitle>BioMed research international</jtitle><addtitle>J Biomed Biotechnol</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>2010</volume><issue>2010</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1110-7243</issn><issn>2314-6133</issn><eissn>1110-7251</eissn><eissn>2314-6141</eissn><abstract>The aims of the present paper were to ascertain whether the heat-induced ischemia and oxidative damage to the hypothalamus and lethality in mice could be ameliorated by hyperbaric oxygen therapy. When normobaric air-treated mice underwent heat treatment, the fractional survival and core temperature at 4 hours after heat stress were found to be 0 of 12 and 34∘C±0.3∘C, respectively. In hyperbaric oxygen-treated mice, when exposed to the same treatment, both fractional survival and core temperature values were significantly increased to new values of 12/12 and 37.3∘C±0.3∘C, respectively. Compared to normobaric air-treated heatstroke mice, hyperbaric oxygen-treated mice displayed lower hypothalamic values of cellular ischemia and damage markers, prooxidant enzymes, proinflammatory cytokines, inducible nitric oxide synthase-dependent nitric oxide, and neuronal damage score. The data indicate that hyperbaric oxygen may improve outcomes of heatstroke by normalization of hypothalamic and thermoregulatory function in mice.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>20625500</pmid><doi>10.1155/2010/609526</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Biomedical research Brain Ischemia - enzymology Brain Ischemia - etiology Brain Ischemia - pathology Brain Ischemia - therapy Cytokines - metabolism Extracellular Space - metabolism Heat Stroke - complications Heat Stroke - pathology Heat Stroke - therapy Heatstroke Hyperbaric Oxygenation Hypothalamus - enzymology Hypothalamus - pathology Inflammation Mediators - metabolism Male Medical research Medical sciences Mice Mice, Inbred ICR Mortality Neurons - metabolism Neurons - pathology Nitric Oxide Synthase Type II - metabolism Oxidative Stress Pharmacology. Drug treatments Proteins Rodents Survival Analysis |
| title | Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice |
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