Molecular Characterization of Heterologous HIV-1gp120 Gene Expression Disruption in Mycobacterium bovis BCG Host Strain : A Critical Issue for Engineering Mycobacterial Based-Vaccine Vectors

Mycobacterium bovis Bacillus Calmette-Guérin (BCG) as a live vector of recombinant bacterial vaccine is a promising system to be used. In this study, we evaluate the disrupted expression of heterologous HIV-1gp120 gene in BCG Pasteur host strain using replicative vectors pMV261 and pJH222. pJH222 ca...

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Veröffentlicht in:	BioMed research international 2010-01, Vol.2010 (2010), p.1-10
Hauptverfasser:	Joseph, Joan, Fernández-Lloris, Raquel, Pezzat, Elías, Saubi, Narcís, Cardona, Pere-Joan, Mothe, Beatriz, Gatell, Josep Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS Vaccines Amino Acid Sequence Bacteria Bacterial diseases Base Sequence BCG Vaccine Biological and medical sciences Blotting, Western E coli Escherichia coli Gene Deletion Gene Expression Genetic Vectors - genetics HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - metabolism Human bacterial diseases Human immunodeficiency virus 1 Human viral diseases Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Medical sciences Molecular Sequence Data Mycobacterium bovis Mycobacterium bovis - genetics Mycobacterium bovis - metabolism Plasmids Polymerase Chain Reaction Transformation, Bacterial Tuberculosis and atypical mycobacterial infections Vaccines, Synthetic Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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