Directed Differentiation of Human‐Induced Pluripotent Stem Cells Generates Active Motor Neurons

The potential for directed differentiation of human‐induced pluripotent stem (iPS) cells to functional postmitotic neuronal phenotypes is unknown. Following methods shown to be effective at generating motor neurons from human embryonic stem cells (hESCs), we found that once specified to a neural lin...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2009-04, Vol.27 (4), p.806-811
Hauptverfasser:	Karumbayaram, Saravanan, Novitch, Bennett G., Patterson, Michaela, Umbach, Joy A., Richter, Laura, Lindgren, Anne, Conway, Anne E., Clark, Amander T., Goldman, Steve A., Plath, Kathrin, Wiedau‐pazos, Martina, Kornblum, Harley I., Lowry, William E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Culture Techniques Cell Differentiation - physiology Cell Line Cell Lineage Embryonic stem cells Embryonic Stem Cells - cytology Humans Motor Neuron Disease - pathology Motor Neuron Disease - therapy Motor Neurons - cytology Motor Neurons - physiology Neural differentiation Neuron Patch-Clamp Techniques Pluripotent stem cell Pluripotent Stem Cells - cytology Regenerative Medicine Reprogramming
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