Doxorubicin-Loaded QuadraSphere Microspheres: Plasma Pharmacokinetics and Intratumoral Drug Concentration in an Animal Model of Liver Cancer

The purpose of this study was to evaluate, in vitro and in vivo, doxorubicin-loaded poly (vinyl alcohol-sodium acrylate) copolymer microspheres [QuadraSphere microspheres (QSMs)] for transcatheter arterial delivery in an animal model of liver cancer. Doxorubicin loading efficiency and release profil...

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Veröffentlicht in:	Cardiovascular and interventional radiology 2010-06, Vol.33 (3), p.576-582
Hauptverfasser:	Lee, Kwang-Hun, Liapi, Eleni A., Cornell, Curt, Reb, Philippe, Buijs, Manon, Vossen, Josephina A., Ventura, Veronica Prieto, Geschwind, Jean-Francois H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins Angiography, Digital Subtraction ANIMALS ANTI-INFECTIVE AGENTS ANTIBIOTICS ANTINEOPLASTIC DRUGS ARTERIES BLOOD VESSELS BODY Cardiology CARDIOVASCULAR SYSTEM Chemoembolization, Therapeutic - instrumentation Contrast Media COPOLYMERS DIGESTIVE SYSTEM Disease Models, Animal DISEASES DOXORUBICIN Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics DRUGS GLANDS Hepatic Artery Imaging Laboratory Investigation LIVER Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - pathology Male MAMMALS Medicine Medicine & Public Health MICROSPHERES NEOPLASMS Nuclear Medicine ORGANIC COMPOUNDS ORGANIC POLYMERS ORGANS POLYMERS Polyvinyls RABBITS Radiology RADIOLOGY AND NUCLEAR MEDICINE Ultrasound VERTEBRATES
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