MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma

Matrix metalloproteinases (MMPs) such as MMP13 promote tumour growth and progression by mediating extracellular matrix (ECM) reorganization and regulating the biological activity of cytokines. Using Mmp13−/− mice, we demonstrate an essential role of this single collagenase for highly malignant and i...

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Veröffentlicht in:	Carcinogenesis (New York) 2010-07, Vol.31 (7), p.1175-1184
Hauptverfasser:	Lederle, Wiltrud, Hartenstein, Bettina, Meides, Alice, Kunzelmann, Heike, Werb, Zena, Angel, Peter, Mueller, Margareta M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cancer Biology Carcinogenesis, carcinogens and anticarcinogens Carcinoma, Squamous Cell - blood supply Cell Line Dermatology Matrix Metalloproteinase 13 - physiology Medical sciences Mice Mice, Inbred C57BL Neoplasm Invasiveness Neovascularization, Pathologic - etiology RNA, Messenger - analysis Skin Neoplasms - blood supply Tumors Tumors of the skin and soft tissue. Premalignant lesions Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - genetics
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