N -Acetylcysteine and 15 Deoxy-Δ12,14 -Prostaglandin J2 Exert a Protective Effect Against Autoimmune Thyroid Destruction in Vivo but Not Against Interleukin-1α/Interferon γ-Induced Inhibitory Effects in Thyrocytes in Vitro

Reactive oxygen species (ROS) are crucial for thyroid hormonogenesis, and their production is kept under tight control. Oxidative stress (OS) is toxic for thyrocytes in an inflammatory context. In vitro , Th1 pro-inflammatory cytokines have already been shown to decrease thyroid-specific protein exp...

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Veröffentlicht in:	The American journal of pathology 2010-07, Vol.177 (1), p.219-228
Hauptverfasser:	Poncin, Sylvie, Colin, Ides M, Decallonne, Brigitte, Clinckspooor, Isabelle, Many, Marie-Christine, Denef, Jean-François, Gérard, Anne-Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Endocrinopathies Investigative techniques, diagnostic techniques (general aspects) Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Regular Thyroid. Thyroid axis (diseases)
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