Altered thermoregulation via sensitization of A1 adenosine receptors in dietary-restricted rats

Rationale Evidence links longevity to dietary restriction (DR). A decrease in body temperature (T b ) is thought to contribute to enhanced longevity because lower T b reduces oxidative metabolism and oxidative stress. It is as yet unclear how DR decreases T b . Objective Here, we test the hypothesis...

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Veröffentlicht in:	Psychopharmacologia 2010-04, Vol.209 (3), p.217-224
Hauptverfasser:	Jinka, Tulasi R., Carlson, Zachary A., Moore, Jeanette T., Drew, Kelly L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine - toxicity Adenosine A1 Receptor Agonists Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Body temperature Body Temperature - drug effects Body Temperature - physiology Body Temperature Regulation - physiology Caloric Restriction Cerebral Cortex - drug effects Cerebral Cortex - metabolism Diet Fasting - metabolism Hypothalamus - drug effects Hypothalamus - metabolism Male Medical sciences Neurosciences Original Investigation Pharmacology/Toxicology Psychiatry Rats Rats, Sprague-Dawley Receptor, Adenosine A1 - metabolism Respiratory Rate - drug effects Rodents Time Factors
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