1H-MRS at 4 Tesla in minimally treated early schizophrenia

We investigated glutamate-related neuronal dysfunction in the anterior cingulate (AC) early in schizophrenia before and after antipsychotic treatment. A total of 14 minimally treated schizophrenia patients and 10 healthy subjects were studied with single-voxel proton magnetic resonance spectroscopy...

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Veröffentlicht in:	Molecular psychiatry 2010-06, Vol.15 (6), p.629-636
Hauptverfasser:	Bustillo, J R, Rowland, L M, Mullins, P, Jung, R, Chen, H, Qualls, C, Hammond, R, Brooks, W M, Lauriello, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Antipsychotics Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Behavioral Sciences Biological Psychology Drug dosages Excitotoxicity Female Frontal Lobe - drug effects Frontal Lobe - metabolism Glutamatergic transmission Glutamic Acid - metabolism Glutamine Glutamine - metabolism Gyrus Cinguli - drug effects Gyrus Cinguli - metabolism Humans Illnesses Ketamine Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Male Medicine Medicine & Public Health Mental disorders N-Acetylaspartate Nerve Fibers, Myelinated - drug effects Nerve Fibers, Myelinated - metabolism Neurological disorders Neurosciences original-article Patients Pharmacotherapy Protons Psychiatry Psychotropic drugs Schizophrenia Schizophrenia - drug therapy Schizophrenia - metabolism Spectrum analysis Substance abuse treatment Substantia alba Thalamus Thalamus - drug effects Thalamus - metabolism Time Factors
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