Sequence features that drive human promoter function and tissue specificity

Promoters are important regulatory elements that contain the necessary sequence features for cells to initiate transcription. To functionally characterize a large set of human promoters, we measured the transcriptional activities of 4575 putative promoters across eight cell lines using transient tra...

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Veröffentlicht in:	Genome research 2010-07, Vol.20 (7), p.890-898
Hauptverfasser:	Landolin, Jane M, Johnson, David S, Trinklein, Nathan D, Aldred, Shelly F, Medina, Catherine, Shulha, Hennady, Weng, Zhiping, Myers, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Composition - physiology Base Sequence - physiology Binding Sites - genetics Cell Line Computational Biology - methods Epigenesis, Genetic - physiology Gene Expression - genetics Gene Expression - physiology Hep G2 Cells Hepatocyte Nuclear Factor 4 - genetics Humans Organ Specificity - genetics Promoter Regions, Genetic - genetics Promoter Regions, Genetic - physiology Protein Binding Transcription, Genetic Transfection
Online-Zugang:	Volltext
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