Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease
Abstract Insulin resistance (IR) is the main pathological condition underlying vascular disorders, such as diabetes and cardiovascular disease, which are well established risk factors for cognitive decline and Alzheimer disease (AD). Hippocampal atrophy has been associated with cognitive decline, bu...
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| Veröffentlicht in: | Neurobiology of aging 2011-11, Vol.32 (11), p.1942-1948 |
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| container_title | Neurobiology of aging |
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| creator | Rasgon, Natalie L Kenna, Heather A Wroolie, Tonita E Kelley, Ryan Silverman, Daniel Brooks, John Williams, Katherine E Powers, Bevin N Hallmayer, Joachim Reiss, Allan |
| description | Abstract Insulin resistance (IR) is the main pathological condition underlying vascular disorders, such as diabetes and cardiovascular disease, which are well established risk factors for cognitive decline and Alzheimer disease (AD). Hippocampal atrophy has been associated with cognitive decline, but little is known about the influence of IR on hippocampus integrity in non-diabetic, cognitively intact individuals. Herein, 50 women ages 50–65, current users of hormone therapy, underwent magnetic resonance imaging, cognitive testing, and homeostatic assessment of insulin resistance (HOMA-IR), as part of a longitudinal study examining brain structure and function in postmenopausal women at risk for AD. Results demonstrated a significant negative relationship between HOMA-IR and right and total hippocampal volume, overall cognitive performance, and selective tests of verbal and non-verbal memory. The main effect of HOMA-IR on brain structure and cognition was not altered by the presence of APOE-ε4 allele or by reproductive history, such as duration of endogenous and exogenous estrogen exposure. These results suggest that IR in middle-aged individuals at risk for AD may be biomarker for dementia risk. |
| doi_str_mv | 10.1016/j.neurobiolaging.2009.12.005 |
| format | Article |
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Hippocampal atrophy has been associated with cognitive decline, but little is known about the influence of IR on hippocampus integrity in non-diabetic, cognitively intact individuals. Herein, 50 women ages 50–65, current users of hormone therapy, underwent magnetic resonance imaging, cognitive testing, and homeostatic assessment of insulin resistance (HOMA-IR), as part of a longitudinal study examining brain structure and function in postmenopausal women at risk for AD. Results demonstrated a significant negative relationship between HOMA-IR and right and total hippocampal volume, overall cognitive performance, and selective tests of verbal and non-verbal memory. The main effect of HOMA-IR on brain structure and cognition was not altered by the presence of APOE-ε4 allele or by reproductive history, such as duration of endogenous and exogenous estrogen exposure. These results suggest that IR in middle-aged individuals at risk for AD may be biomarker for dementia risk.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2009.12.005</identifier><identifier>PMID: 20031276</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Aged ; Alleles ; Alzheimer Disease - genetics ; Alzheimer Disease - pathology ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; APOE-ε4 ; Apolipoprotein E4 - genetics ; Atrophy - pathology ; Atrophy - physiopathology ; Biological and medical sciences ; Cognition ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia risk ; Development. Senescence. Regeneration. Transplantation ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Genotype ; Hippocampal volume ; Hippocampus - pathology ; Hippocampus - physiopathology ; Humans ; Insulin resistance ; Insulin Resistance - physiology ; Internal Medicine ; Longitudinal Studies ; Medical sciences ; Memory ; Middle Aged ; Neurology ; Neuropsychological Tests ; Organ Size ; Postmenopausal women ; Risk Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurobiology of aging, 2011-11, Vol.32 (11), p.1942-1948</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2009 Elsevier Inc. 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Hippocampal atrophy has been associated with cognitive decline, but little is known about the influence of IR on hippocampus integrity in non-diabetic, cognitively intact individuals. Herein, 50 women ages 50–65, current users of hormone therapy, underwent magnetic resonance imaging, cognitive testing, and homeostatic assessment of insulin resistance (HOMA-IR), as part of a longitudinal study examining brain structure and function in postmenopausal women at risk for AD. Results demonstrated a significant negative relationship between HOMA-IR and right and total hippocampal volume, overall cognitive performance, and selective tests of verbal and non-verbal memory. The main effect of HOMA-IR on brain structure and cognition was not altered by the presence of APOE-ε4 allele or by reproductive history, such as duration of endogenous and exogenous estrogen exposure. These results suggest that IR in middle-aged individuals at risk for AD may be biomarker for dementia risk.</description><subject>Aged</subject><subject>Alleles</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>APOE-ε4</subject><subject>Apolipoprotein E4 - genetics</subject><subject>Atrophy - pathology</subject><subject>Atrophy - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Cognition</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia risk</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Hippocampal volume</subject><subject>Hippocampus - pathology</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Internal Medicine</subject><subject>Longitudinal Studies</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Organ Size</subject><subject>Postmenopausal women</subject><subject>Risk Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAUhSMEokPhFVAWoK4SbMe_EqpUVRQqVULiZ205zs2Mp4kd7GRQeXo8mqFQNrDywt85vtZ3i-IVRjVGmL_Z1h6WGFoXBrN2fl0ThFSNSY0Qe1SsMGOywlSJx8UKYSUqyiQ6KZ6ltEUICSr40-IkRxpMBF8Vn659WgbnywjJpdl4C6XxXblx0xSsGSczlLswLCOUGfoeRvClmcvo0m3Zh1heDD824EaIZ6nsXAKT4HnxpDdDghfH87T4evXuy-WH6ubj--vLi5vKiobPVdszpogwXFIuOtxK0ba85xZQ2zSIIoZFD70EglljG4V7i7hqpOI9owo1qjktzg-909KO0FnwczSDnqIbTbzTwTj98Ma7jV6HnSZSYUVYLjg7FsTwbYE069ElC8NgPIQlaYUElpjQf5NSKkoloTiTbw-kjSGlCP39PBjpvT-91Q_96b0_jYnO_nL85Z9_ug__EpaB10fAJGuGPmZjLv3mKFeUUZK5qwMH2cDOQdTJOsh2OxfBzroL7n8nOv-ryOZ1cfntW7iDtA1L9NmyxjrlgP6837n9yiGVR1aCND8BodHXTQ</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Rasgon, Natalie L</creator><creator>Kenna, Heather A</creator><creator>Wroolie, Tonita E</creator><creator>Kelley, Ryan</creator><creator>Silverman, Daniel</creator><creator>Brooks, John</creator><creator>Williams, Katherine E</creator><creator>Powers, Bevin N</creator><creator>Hallmayer, Joachim</creator><creator>Reiss, Allan</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20111101</creationdate><title>Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease</title><author>Rasgon, Natalie L ; Kenna, Heather A ; Wroolie, Tonita E ; Kelley, Ryan ; Silverman, Daniel ; Brooks, John ; Williams, Katherine E ; Powers, Bevin N ; Hallmayer, Joachim ; Reiss, Allan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c736t-bf55927a68467d1b87bb6f6ce0b33040517fef8e2153c391fc0693896f5490393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer's disease</topic><topic>APOE-ε4</topic><topic>Apolipoprotein E4 - genetics</topic><topic>Atrophy - pathology</topic><topic>Atrophy - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Cognition</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia risk</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Hippocampal volume</topic><topic>Hippocampus - pathology</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Internal Medicine</topic><topic>Longitudinal Studies</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Organ Size</topic><topic>Postmenopausal women</topic><topic>Risk Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rasgon, Natalie L</creatorcontrib><creatorcontrib>Kenna, Heather A</creatorcontrib><creatorcontrib>Wroolie, Tonita E</creatorcontrib><creatorcontrib>Kelley, Ryan</creatorcontrib><creatorcontrib>Silverman, Daniel</creatorcontrib><creatorcontrib>Brooks, John</creatorcontrib><creatorcontrib>Williams, Katherine E</creatorcontrib><creatorcontrib>Powers, Bevin N</creatorcontrib><creatorcontrib>Hallmayer, Joachim</creatorcontrib><creatorcontrib>Reiss, Allan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasgon, Natalie L</au><au>Kenna, Heather A</au><au>Wroolie, Tonita E</au><au>Kelley, Ryan</au><au>Silverman, Daniel</au><au>Brooks, John</au><au>Williams, Katherine E</au><au>Powers, Bevin N</au><au>Hallmayer, Joachim</au><au>Reiss, Allan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>32</volume><issue>11</issue><spage>1942</spage><epage>1948</epage><pages>1942-1948</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Abstract Insulin resistance (IR) is the main pathological condition underlying vascular disorders, such as diabetes and cardiovascular disease, which are well established risk factors for cognitive decline and Alzheimer disease (AD). Hippocampal atrophy has been associated with cognitive decline, but little is known about the influence of IR on hippocampus integrity in non-diabetic, cognitively intact individuals. Herein, 50 women ages 50–65, current users of hormone therapy, underwent magnetic resonance imaging, cognitive testing, and homeostatic assessment of insulin resistance (HOMA-IR), as part of a longitudinal study examining brain structure and function in postmenopausal women at risk for AD. Results demonstrated a significant negative relationship between HOMA-IR and right and total hippocampal volume, overall cognitive performance, and selective tests of verbal and non-verbal memory. The main effect of HOMA-IR on brain structure and cognition was not altered by the presence of APOE-ε4 allele or by reproductive history, such as duration of endogenous and exogenous estrogen exposure. These results suggest that IR in middle-aged individuals at risk for AD may be biomarker for dementia risk.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>20031276</pmid><doi>10.1016/j.neurobiolaging.2009.12.005</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Alleles Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease APOE-ε4 Apolipoprotein E4 - genetics Atrophy - pathology Atrophy - physiopathology Biological and medical sciences Cognition Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia risk Development. Senescence. Regeneration. Transplantation Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genotype Hippocampal volume Hippocampus - pathology Hippocampus - physiopathology Humans Insulin resistance Insulin Resistance - physiology Internal Medicine Longitudinal Studies Medical sciences Memory Middle Aged Neurology Neuropsychological Tests Organ Size Postmenopausal women Risk Factors Vertebrates: nervous system and sense organs |
| title | Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease |
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