Aspergillus fumigatus Conidial Melanin Modulates Host Cytokine Response

Abstract Melanin biopigments have been linked to fungal virulence. Aspergillus fumigatus conidia are melanised and are weakly immunogenic. We show that melanin pigments on the surface of resting Aspergillus fumigatus conidia may serve to mask pathogen-associated molecular patterns (PAMPs)-induced cy...

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Veröffentlicht in:	Immunobiology (1979) 2010-11, Vol.215 (11), p.915-920
Hauptverfasser:	Chai, Louis Y.A, Netea, Mihai G, Sugui, Janyce, Vonk, Alieke G, van de Sande, Wendy W.J, Warris, Adilia, Kwon-Chung, Kyung J, Jan Kullberg, Bart
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy and Immunology Aspergillosis - immunology Aspergillosis - microbiology Aspergillus fumigatus Aspergillus fumigatus - immunology Aspergillus fumigatus - pathogenicity Cells, Cultured Cytokines - biosynthesis Dectin-1 Host-Pathogen Interactions Humans Leukocytes, Mononuclear Mannan Mannose receptor Melanin Melanins - immunology Modulation Spores, Fungal - immunology Virulence β-glucan
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