CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis

Experimental autoimmune glomerulonephritis (EAG), an animal model of Goodpasture's disease, can be induced in Wistar Kyoto (WKY) rats by a single injection of rat glomerular basement membrane (GBM) in adjuvant. EAG is characterized by circulating and deposited anti-GBM antibodies, accompanied b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2000-03, Vol.105 (5), p.643-651
Hauptverfasser:	Reynolds, J, Tam, F W, Chandraker, A, Smith, J, Karkar, A M, Cross, J, Peach, R, Sayegh, M H, Pusey, C D
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Animals Anti-Glomerular Basement Membrane Disease - immunology Antigens, CD Antigens, Differentiation - genetics Antigens, Differentiation - pharmacology Autoantibodies - immunology Autoimmune Diseases - immunology B7-1 Antigen - immunology Basement Membrane - immunology CD28 Antigens - immunology CTLA-4 Antigen Disease Models, Animal Fibrin - metabolism Fluorescent Antibody Technique Glomerulonephritis - immunology Immunoconjugates Immunoglobulin G - blood Kidney - immunology Kidney - pathology Mutation Rats Rats, Inbred Strains T-Lymphocytes - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!