Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

Lipopolysaccharide (LPS) is the main inducer of shock and death in Gram-negative sepsis. Recent evidence suggests that LPS-induced signal transduction begins with CD14-mediated activation of 1 or more Toll-like receptors (TLRs). The lipid A analogues lipid IVa and Rhodobacter sphaeroides lipid A (RS...

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Veröffentlicht in:	The Journal of clinical investigation 2000-02, Vol.105 (4), p.497-504
Hauptverfasser:	Lien, E, Means, T K, Heine, H, Yoshimura, A, Kusumoto, S, Fukase, K, Fenton, M J, Oikawa, M, Qureshi, N, Monks, B, Finberg, R W, Ingalls, R R, Golenbock, D T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CHO Cells Cricetinae Drosophila Proteins Glycolipids - metabolism Humans Ligands Lipid A - analogs & derivatives Lipid A - metabolism Lipopolysaccharide Receptors - genetics Lipopolysaccharide Receptors - metabolism Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - metabolism Macrophages - cytology Macrophages - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Molecular Mimicry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Recombinant Proteins - metabolism Rhodobacter sphaeroides Signal Transduction Species Specificity Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors
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