TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

Transforming growth factor β (TGF-β) plays an important role in tumor initiation and progression, functioning as both a suppressor and a promoter. The mechanisms underlying this dual role of TGF-β remain unclear. TGF-β exerts systemic immune suppression and inhibits host immunosurveillance. Neutrali...

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Veröffentlicht in:	Trends in immunology 2010-06, Vol.31 (6), p.220-227
Hauptverfasser:	Yang, Li, Pang, Yanli, Moses, Harold L
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Disease Progression Humans Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Neoplasms - drug therapy Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Signal Transduction T-Lymphocytes - immunology T-Lymphocytes - metabolism Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - immunology Transforming Growth Factor beta - metabolism
Online-Zugang:	Volltext
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