The functions of key residues in the inhibitor, substrate and cofactor sites of human 3β-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis

In postmenopausal women, human 3β-hydroxysteroid dehydrogenase type 1 (3β-HSD1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, while 3β-HSD2 participates in the production of cortisol and aldosterone in the human adrenal gland. The goals of this project are to determin...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2010-06, Vol.120 (4-5), p.192-199
Hauptverfasser:	Thomas, James L., Mack, Vance L., Sun, Jingping, Terrell, J. Ross, Bucholtz, Kevin M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3β-Hydroxysteroid dehydrogenase Biological and medical sciences Fundamental and applied biological sciences. Psychology Mutagenesis Short-chain dehydrogenase/reductase Structure–function relationship Vertebrates: endocrinology Vertebrates: reproduction
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