Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

Edmonston vaccine strains of measles virus (MV) have shown significant antitumor activity in preclinical models of ovarian cancer. We engineered MV to express the marker peptide carcinoembryonic antigen (MV-CEA virus) to also permit real-time monitoring of viral gene expression in tumors in the clin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-02, Vol.70 (3), p.875-882
Hauptverfasser:	GALANIS, Evanthia, HARTMANN, Lynn C, SLOAN, Jeff A, KEENEY, Gary, ATHERTON, Pamela J, PODRATZ, Karl C, DOWDY, Sean C, STANHOPE, C. Robert, WILSON, Timothy O, FEDERSPIEL, Mark J, PENG, Kah-Whye, RUSSELL, Stephen J, CLIBY, William A, LONG, Harry J, PEETHAMBARAM, Prema P, BARRETTE, Brigitte A, KAUR, Judith S, HALUSKA, Paul J, ADERCA, Ileana, ZMAN, Paula J
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Pain - etiology Adult Aged Aged, 80 and over Animals Antineoplastic agents Biological and medical sciences Carcinoembryonic Antigen - genetics Carcinoembryonic Antigen - metabolism Cercopithecus aethiops Fatigue - etiology Female Female genital diseases Fever - etiology Gynecology. Andrology. Obstetrics Humans Injections, Intraperitoneal Measles virus - genetics Measles virus - physiology Medical sciences Middle Aged Neoplasm Recurrence, Local Oncolytic Virotherapy - adverse effects Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Oncolytic Viruses - physiology Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Pharmacology. Drug treatments Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - adverse effects Treatment Outcome Tumors Vero Cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!