Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study
BackgroundAsthma is considered to be associated with elevated levels of exhaled nitric oxide (FeNO). The nature of this relationship and how it is influenced by atopy are still not resolved.MethodsThe Isle of Wight birth cohort (N=1456) was reassessed at 18 years of age. Participants able to attend...
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| Veröffentlicht in: | Thorax 2010-03, Vol.65 (3), p.258-262 |
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| creator | Scott, Martha Raza, Abid Karmaus, Wilfried Mitchell, Frances Grundy, Jane Kurukulaaratchy, Ramesh J Arshad, S Hasan Roberts, Graham |
| description | BackgroundAsthma is considered to be associated with elevated levels of exhaled nitric oxide (FeNO). The nature of this relationship and how it is influenced by atopy are still not resolved.MethodsThe Isle of Wight birth cohort (N=1456) was reassessed at 18 years of age. Participants able to attend the research centre were assessed by questionnaires, skin prick testing and FeNO in order to explore the interrelationship between asthma, atopy and FeNO.ResultsAtopy was significantly associated with higher levels of FeNO. However, the level of FeNO for non-atopic asthmatic participants was no different to the non-atopic no-asthma group. The highest levels of FeNO were seen in subjects with both atopy and asthma. In addition, FeNO was positively associated with increasing atopic burden as evidenced by increasing FeNO with increasing skin prick testing positivity, and with increasing severity of atopic asthma as evidenced by the number of attacks of wheezing. FeNO and current inhaled corticosteroid use were not significantly associated.ConclusionsFeNO behaves as a biomarker of atopy and the “allergic asthma” phenotype rather than asthma itself. This may explain why FeNO-guided asthma treatment outcomes have proved to be of limited success where atopic status has not been considered and accounted for. |
| doi_str_mv | 10.1136/thx.2009.125443 |
| format | Article |
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The nature of this relationship and how it is influenced by atopy are still not resolved.MethodsThe Isle of Wight birth cohort (N=1456) was reassessed at 18 years of age. Participants able to attend the research centre were assessed by questionnaires, skin prick testing and FeNO in order to explore the interrelationship between asthma, atopy and FeNO.ResultsAtopy was significantly associated with higher levels of FeNO. However, the level of FeNO for non-atopic asthmatic participants was no different to the non-atopic no-asthma group. The highest levels of FeNO were seen in subjects with both atopy and asthma. In addition, FeNO was positively associated with increasing atopic burden as evidenced by increasing FeNO with increasing skin prick testing positivity, and with increasing severity of atopic asthma as evidenced by the number of attacks of wheezing. FeNO and current inhaled corticosteroid use were not significantly associated.ConclusionsFeNO behaves as a biomarker of atopy and the “allergic asthma” phenotype rather than asthma itself. This may explain why FeNO-guided asthma treatment outcomes have proved to be of limited success where atopic status has not been considered and accounted for.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thx.2009.125443</identifier><identifier>PMID: 20335297</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Thoracic Society</publisher><subject>Adolescence ; Adolescent ; Asthma ; Asthma - immunology ; Asthma - metabolism ; atopy ; Biological and medical sciences ; Biomarkers - metabolism ; birth cohort ; Body Height ; Body Mass Index ; Breath Tests - methods ; Cardiology. Vascular system ; Chronic obstructive pulmonary disease, asthma ; Cohort analysis ; Cohort Studies ; Data collection ; Education ; exhaled nitric oxide ; Female ; Gender ; Humans ; Hypersensitivity, Immediate - metabolism ; Male ; Medical sciences ; Nitric oxide ; Nitric Oxide - metabolism ; Pneumology ; Questionnaires ; Rhinitis ; Sex Factors ; Skin ; Smoking - metabolism ; Spirometry ; Steroids</subject><ispartof>Thorax, 2010-03, Vol.65 (3), p.258-262</ispartof><rights>2010, Published by the BMJ Publishing Group Limited For permission to use, (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2010 (c) 2010, Published by the BMJ Publishing Group Limited For permission to use, (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b589t-eabbb7b1d62791e17554a95f2bbf2c3839a5fff485b4930001354a613ac7c43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://thorax.bmj.com/content/65/3/258.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://thorax.bmj.com/content/65/3/258.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,776,780,881,3183,23550,27901,27902,77342,77373</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22469186$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20335297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scott, Martha</creatorcontrib><creatorcontrib>Raza, Abid</creatorcontrib><creatorcontrib>Karmaus, Wilfried</creatorcontrib><creatorcontrib>Mitchell, Frances</creatorcontrib><creatorcontrib>Grundy, Jane</creatorcontrib><creatorcontrib>Kurukulaaratchy, Ramesh J</creatorcontrib><creatorcontrib>Arshad, S Hasan</creatorcontrib><creatorcontrib>Roberts, Graham</creatorcontrib><title>Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study</title><title>Thorax</title><addtitle>Thorax</addtitle><description>BackgroundAsthma is considered to be associated with elevated levels of exhaled nitric oxide (FeNO). The nature of this relationship and how it is influenced by atopy are still not resolved.MethodsThe Isle of Wight birth cohort (N=1456) was reassessed at 18 years of age. Participants able to attend the research centre were assessed by questionnaires, skin prick testing and FeNO in order to explore the interrelationship between asthma, atopy and FeNO.ResultsAtopy was significantly associated with higher levels of FeNO. However, the level of FeNO for non-atopic asthmatic participants was no different to the non-atopic no-asthma group. The highest levels of FeNO were seen in subjects with both atopy and asthma. In addition, FeNO was positively associated with increasing atopic burden as evidenced by increasing FeNO with increasing skin prick testing positivity, and with increasing severity of atopic asthma as evidenced by the number of attacks of wheezing. FeNO and current inhaled corticosteroid use were not significantly associated.ConclusionsFeNO behaves as a biomarker of atopy and the “allergic asthma” phenotype rather than asthma itself. This may explain why FeNO-guided asthma treatment outcomes have proved to be of limited success where atopic status has not been considered and accounted for.</description><subject>Adolescence</subject><subject>Adolescent</subject><subject>Asthma</subject><subject>Asthma - immunology</subject><subject>Asthma - metabolism</subject><subject>atopy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>birth cohort</subject><subject>Body Height</subject><subject>Body Mass Index</subject><subject>Breath Tests - methods</subject><subject>Cardiology. Vascular system</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Data collection</subject><subject>Education</subject><subject>exhaled nitric oxide</subject><subject>Female</subject><subject>Gender</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Pneumology</subject><subject>Questionnaires</subject><subject>Rhinitis</subject><subject>Sex Factors</subject><subject>Skin</subject><subject>Smoking - metabolism</subject><subject>Spirometry</subject><subject>Steroids</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0c2LEzEYBvBBFLeunr1JQEQQppuvSTIXQYrrLhQVFNFTSDIZJ3Wa1CQj7X9vytT6cfGUw_PLy_vyVNVjBJcIEXaVh_0SQ9guEW4oJXeqBaJM1AS37G61gJDCmhHOLqoHKW0ghAIhfr-6wJCQBrd8UX259f04WW8sCD1QOewOQPkOqJSHrQLBA7sf1Gg74F2OzoCwd50FzhcFJp_saE0uqXYxD8CEIcQMUp66w8PqXq_GZB-d3svqw_Xrj6ubev3uze3q1brWjWhzbZXWmmvUMcxbZBFvGqrapsda99gQQVrV9H1PRaNpS8oJiBTAEFGGG0ouq5fz1N2kt7Yz1ueoRrmLbqviQQbl5N-Jd4P8Gn5ILFoIOSwDnp8GxPB9sinLrUvGjqPyNkxJckIoEZygIp_-Izdhir7cJhEXSGDG-VFdzcrEkFK0_XkXBOWxM1k6k8fO5NxZ-fHkzxPO_ldJBTw7AZWMGvuovHHpt8OUtUiw4urZuZTt_pyr-E0yTngj335ayWvxvoE3n9dyXfyL2evt5r9b_gSKHbw7</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Scott, Martha</creator><creator>Raza, Abid</creator><creator>Karmaus, Wilfried</creator><creator>Mitchell, Frances</creator><creator>Grundy, Jane</creator><creator>Kurukulaaratchy, Ramesh J</creator><creator>Arshad, S Hasan</creator><creator>Roberts, Graham</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100301</creationdate><title>Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study</title><author>Scott, Martha ; Raza, Abid ; Karmaus, Wilfried ; Mitchell, Frances ; Grundy, Jane ; Kurukulaaratchy, Ramesh J ; Arshad, S Hasan ; Roberts, Graham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b589t-eabbb7b1d62791e17554a95f2bbf2c3839a5fff485b4930001354a613ac7c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescence</topic><topic>Adolescent</topic><topic>Asthma</topic><topic>Asthma - immunology</topic><topic>Asthma - metabolism</topic><topic>atopy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>birth cohort</topic><topic>Body Height</topic><topic>Body Mass Index</topic><topic>Breath Tests - methods</topic><topic>Cardiology. Vascular system</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Data collection</topic><topic>Education</topic><topic>exhaled nitric oxide</topic><topic>Female</topic><topic>Gender</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Pneumology</topic><topic>Questionnaires</topic><topic>Rhinitis</topic><topic>Sex Factors</topic><topic>Skin</topic><topic>Smoking - metabolism</topic><topic>Spirometry</topic><topic>Steroids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scott, Martha</creatorcontrib><creatorcontrib>Raza, Abid</creatorcontrib><creatorcontrib>Karmaus, Wilfried</creatorcontrib><creatorcontrib>Mitchell, Frances</creatorcontrib><creatorcontrib>Grundy, Jane</creatorcontrib><creatorcontrib>Kurukulaaratchy, Ramesh J</creatorcontrib><creatorcontrib>Arshad, S Hasan</creatorcontrib><creatorcontrib>Roberts, Graham</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scott, Martha</au><au>Raza, Abid</au><au>Karmaus, Wilfried</au><au>Mitchell, Frances</au><au>Grundy, Jane</au><au>Kurukulaaratchy, Ramesh J</au><au>Arshad, S Hasan</au><au>Roberts, Graham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>65</volume><issue>3</issue><spage>258</spage><epage>262</epage><pages>258-262</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>BackgroundAsthma is considered to be associated with elevated levels of exhaled nitric oxide (FeNO). The nature of this relationship and how it is influenced by atopy are still not resolved.MethodsThe Isle of Wight birth cohort (N=1456) was reassessed at 18 years of age. Participants able to attend the research centre were assessed by questionnaires, skin prick testing and FeNO in order to explore the interrelationship between asthma, atopy and FeNO.ResultsAtopy was significantly associated with higher levels of FeNO. However, the level of FeNO for non-atopic asthmatic participants was no different to the non-atopic no-asthma group. The highest levels of FeNO were seen in subjects with both atopy and asthma. In addition, FeNO was positively associated with increasing atopic burden as evidenced by increasing FeNO with increasing skin prick testing positivity, and with increasing severity of atopic asthma as evidenced by the number of attacks of wheezing. FeNO and current inhaled corticosteroid use were not significantly associated.ConclusionsFeNO behaves as a biomarker of atopy and the “allergic asthma” phenotype rather than asthma itself. This may explain why FeNO-guided asthma treatment outcomes have proved to be of limited success where atopic status has not been considered and accounted for.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Thoracic Society</pub><pmid>20335297</pmid><doi>10.1136/thx.2009.125443</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescence Adolescent Asthma Asthma - immunology Asthma - metabolism atopy Biological and medical sciences Biomarkers - metabolism birth cohort Body Height Body Mass Index Breath Tests - methods Cardiology. Vascular system Chronic obstructive pulmonary disease, asthma Cohort analysis Cohort Studies Data collection Education exhaled nitric oxide Female Gender Humans Hypersensitivity, Immediate - metabolism Male Medical sciences Nitric oxide Nitric Oxide - metabolism Pneumology Questionnaires Rhinitis Sex Factors Skin Smoking - metabolism Spirometry Steroids |
| title | Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study |
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