Genetic and Structural Characterization of L11 Lipooligosaccharide from Neisseria meningitidis Serogroup A Strains

The lipooligosaccharide (LOS) of immunotype L11 is unique within serogroup A meningococci. In order to resolve its molecular structure, we conducted LOS genotyping by PCR analysis of genes responsible for α-chain sugar addition (lgtA, -B, -C, -E, -H, and -F) and inner core substituents (lgtG, lpt-3,...

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Veröffentlicht in:	The Journal of biological chemistry 2010-06, Vol.285 (26), p.19874-19883
Hauptverfasser:	Mistretta, Noëlle, Seguin, Delphine, Thiébaud, Jerôme, Vialle, Sandrine, Blanc, Frédéric, Brossaud, Marina, Talaga, Philippe, Norheim, Gunnstein, Moreau, Monique, Rokbi, Bachra
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacterial Genetics Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Carbohydrate Sequence Carbohydrate Structure DNA, Bacterial - chemistry DNA, Bacterial - genetics Electrophoresis, Polyacrylamide Gel Gas Chromatography-Mass Spectrometry Gel Electrophoresis Gene Amplification Gene Expression Glycosylation Glycosyltransferases - genetics Glycosyltransferases - metabolism Humans Lipopolysaccharide (LPS) Lipopolysaccharides - biosynthesis Lipopolysaccharides - chemistry Magnetic Resonance Spectroscopy Meningitis, Meningococcal - microbiology Microbiology Molecular Sequence Data Molecular Structure Monosaccharides - analysis N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism Neisseria meningitidis Neisseria meningitidis, Serogroup A - classification Neisseria meningitidis, Serogroup A - genetics Neisseria meningitidis, Serogroup A - metabolism Sequence Analysis, DNA Serotyping Species Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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