Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study

We aimed to replicate the strong associations that a recent genome wide association study (GWAS) has found between 16 single nucleotide polymorphisms (SNPs) and response to anti-tumour necrosis factor (TNF) treatment in 89 patients with rheumatoid arthritis (RA). This study is very important because...

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Veröffentlicht in:	Arthritis research & therapy 2010-01, Vol.12 (2), p.R72-R72, Article R72
Hauptverfasser:	Suarez-Gestal, Marian, Perez-Pampin, Eva, Calaza, Manuel, Gomez-Reino, Juan J, Gonzalez, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - physiopathology Development and progression DNA replication Etanercept Female Genetic aspects Genetic Predisposition to Disease Genome-Wide Association Study Health Status Humans Identification and classification Immunoglobulin G - therapeutic use Infliximab Linear models (Statistics) Linear regression models Male Middle Aged Polymorphism, Single Nucleotide - genetics Properties Prospective Studies Receptors, Tumor Necrosis Factor - therapeutic use Reproducibility of Results Research article Rheumatoid arthritis Severity of Illness Index Single nucleotide polymorphisms Treatment Failure Tumor necrosis factor Tumor Necrosis Factor-alpha - antagonists & inhibitors
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