genome of Streptococcus pneumoniae is organized in topology-reacting gene clusters

The transcriptional response of Streptococcus pneumoniae was examined after exposure to the GyrB-inhibitor novobiocin. Topoisomer distributions of an internal plasmid confirmed DNA relaxation and recovery of the native level of supercoiling at low novobiocin concentrations. This was due to the up-re...

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Veröffentlicht in:	Nucleic acids research 2010-06, Vol.38 (11), p.3570-3581
Hauptverfasser:	Ferrándiz, María-José, Martín-Galiano, Antonio J, Schvartzman, Jorge B, de la Campa, Adela G
Format:	Artikel
Sprache:	eng
Schlagworte:	Codon DNA Topoisomerases, Type I - genetics DNA Topoisomerases, Type I - metabolism DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - metabolism DNA, Bacterial - chemistry DNA, Superhelical - metabolism Enzyme Inhibitors - pharmacology Gene Expression Regulation, Bacterial Genome, Bacterial Genomics Novobiocin - pharmacology RNA, Messenger - metabolism Streptococcus pneumoniae Streptococcus pneumoniae - enzymology Streptococcus pneumoniae - genetics Topoisomerase II Inhibitors Transcription, Genetic
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