β-Arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase

A major source of "high-output" NO in inflammation is inducible nitric oxide synthase (iNOS). iNOS is primarily transcriptionally regulated and is thought to function as an uncontrolled generator of high NO. We found that iNOS in cytokine-stimulated human lung microvascular endothelial cel...

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Veröffentlicht in:	The FASEB journal 2010-07, Vol.24 (7), p.2475-2483
Hauptverfasser:	Kuhr, Frank K, Zhang, Yongkang, Brovkovych, Viktor, Skidgel, Randal A
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrestins - physiology beta-Arrestin 1 beta-Arrestin 2 beta-Arrestins Cell Line Endothelium, Vascular - cytology Enzyme Activation Extracellular Signal-Regulated MAP Kinases - metabolism Humans Inflammation Lung - blood supply Nitric Oxide Synthase Type II - metabolism Receptor, Bradykinin B1 - metabolism Research Communications
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