heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release

Heparin-binding EGF-like growth factor (HB-EGF) is a ligand for EGF receptor (EGFR) and possesses the ability to signal in juxtacrine, autocrine and/or paracrine mode, with these alternatives being governed by the degree of proteolytic release of the ligand. Although the spatial range of diffusion o...

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Veröffentlicht in:	Journal of cell science 2010-07, Vol.123 (13), p.2308-2318
Hauptverfasser:	Prince, Robin N, Schreiter, Eric R, Zou, Peng, Wiley, H. Steven, Ting, Alice Y, Lee, Richard T, Lauffenburger, Douglas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amphiregulin Animals BASIC BIOLOGICAL SCIENCES Cell Communication - physiology Cell Proliferation Cell-cell contact Cercopithecus aethiops COS Cells DIFFUSION EGF Family of Proteins GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE Glycoproteins - metabolism GROWTH GROWTH FACTORS Heparan Sulfate Proteoglycans - metabolism Heparan-sulfate proteoglycan (HSPG) Heparin - genetics Heparin - metabolism Heparin binding Heparin-binding EGF-like Growth Factor Heparin-binding epidermal-growth-factor-like growth factor (HB-EGF) INHIBITION Intercellular Junctions Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Juxtacrine Mice Molecular Sequence Data Mutation Peptides - genetics Peptides - metabolism PHENOTYPE PROLIFERATION Protein Precursors - genetics Protein Precursors - metabolism Protein Structure, Tertiary PROTEINS
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