Down-regulation of Epidermal Growth Factor Receptor by Selective Expansion of a 5'-End Regulatory Dinucleotide Repeat in Colon Cancer with Microsatellite Instability

The epidermal growth factor receptor (EGFR) is overexpressed in several tumor types, and its expression is influenced by the length of a 5'-end microsatellite repeat (CA)n: the longer the repeat, the lower the expression. Dinucleotide repeats accumulate insertion/deletion types of mutations in...

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Veröffentlicht in:	Clinical cancer research 2009-07, Vol.15 (14), p.4531-4537
Hauptverfasser:	BARANOVSKAYA, Svetlana, MARTIN, Yolanda, PERUCHO, Manuel, MALKHOSYAN, Sergei R, ALONSO, Sergio, PISARCHUK, Ksenia L, FALCHETTI, Mario, DAI, Yuichi, KHALDOYANID, Sophia, KRAJEWSKI, Stan, NOVIKOVA, Inna, SIDORENKO, Yuri S
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Base Sequence Cell Line, Tumor Colonic Neoplasms - genetics Colonic Neoplasms - pathology Dinucleotide Repeats - genetics DNA Mutational Analysis Down-Regulation ErbB Receptors - genetics Flow Cytometry Gene Frequency Genes, ras - genetics Genotype Humans Microsatellite Instability Mutagenesis, Insertional Mutation Poly A - genetics Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Proto-Oncogene Proteins B-raf - genetics Sequence Deletion Stomach Neoplasms - genetics Stomach Neoplasms - pathology Tumor Suppressor Protein p53 - genetics
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