Neural Origins of Human Sickness in Interoceptive Responses to Inflammation

Background Inflammation is associated with psychological, emotional, and behavioral disturbance, known as sickness behavior. Inflammatory cytokines are implicated in coordinating this central motivational reorientation accompanying peripheral immunologic responses to pathogens. Studies in rodents su...

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Veröffentlicht in:	Biological psychiatry (1969) 2009-09, Vol.66 (5), p.415-422
Hauptverfasser:	Harrison, Neil A, Brydon, Lena, Walker, Cicely, Gray, Marcus A, Steptoe, Andrew, Dolan, Raymond J, Critchley, Hugo D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Affect - physiology Archival Report Brain - physiopathology Cytokines fatigue fMRI Humans Illness Behavior - physiology Inflammation - blood Inflammation - physiopathology Inflammation - psychology insula Interleukin-6 - blood interoception Magnetic Resonance Imaging Male Neural Pathways - physiopathology peripheral inflammation Psychiatry Psychomotor Performance - physiology Typhoid-Paratyphoid Vaccines
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