Inhibition of NF-κB Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin

Colorectal cancer is the third most common malignancy in the United States. Modest advances with therapeutic approaches that include oxaliplatin (l-OHP) have brought the median survival rate to 22 months, with drug resistance remaining a significant barrier. Tumor necrosis factor-related apoptosis-i...

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Veröffentlicht in:	The Journal of biological chemistry 2010-06, Vol.285 (25), p.19162-19172
Hauptverfasser:	Jani, Tanvi S., DeVecchio, Jennifer, Mazumdar, Tapati, Agyeman, Akwasi, Houghton, Janet A.
Format:	Artikel
Sprache:	eng
Schlagworte:	c-FLIP Cell Death Colon Cancer Mcl-1 NF-κB shRNA Signal Transduction Survival Signaling TRAIL
Online-Zugang:	Volltext
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