High prevalence of plasmid-mediated quinolone resistance determinants in commensal members of the Enterobacteriaceae in Ho Chi Minh City, Vietnam
1 Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam 2 Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK 3 Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam 4 Hung Vuong Hospital, Ho Chi Minh C...
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| Veröffentlicht in: | Journal of medical microbiology 2009-12, Vol.58 (12), p.1585-1592 |
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| creator | Minh Vien, Le Thi Baker, Stephen Phuong Thao, Le Thi Phuong Tu, Le Thi Thu Thuy, Cao Thu Nga, Tran Thi Minh Hoang, Nguyen Van Campbell, James Iain Minh Yen, Lam Trong Hieu, Nguyen Vinh Chau, Nguyen Van Farrar, Jeremy Schultsz, Constance |
| description | 1 Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
2 Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
3 Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
4 Hung Vuong Hospital, Ho Chi Minh City, Vietnam
5 Center for Poverty-related Communicable Diseases (CPCD), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Correspondence Constance Schultsz schultsz{at}gmail.com
Received February 4, 2009
Accepted August 14, 2009
Antimicrobial-resistant pathogenic members of the Enterobacteriaceae are a well-defined global problem. We hypothesized that one of the main reservoirs of dissemination of antimicrobial resistance genes in Vietnam is non-pathogenic intestinal flora, and sought to isolate antimicrobial-resistant organisms from hospitalized patients and non-hospitalized healthy individuals in Ho Chi Minh City. The results identified substantial faecal carriage of gentamicin-, ceftazidime- and nalidixic acid-resistant members of the Enterobacteriaceae in both hospitalized patients and non-hospitalized healthy individuals. A high prevalence of quinolone resistance determinants was identified, particularly the qnrS gene, in both community- and hospital-associated strains. Furthermore, the results demonstrated that a combination of quinolone resistance determinants can confer resistance to nalidixic acid and ciprofloxacin, even in the apparent absence of additional chromosomal resistance mutations in wild-type strains and laboratory strains with transferred plasmids. These data suggest that intestinal commensal organisms are a significant reservoir for the dissemination of plasmid-mediated quinolone resistance in Ho Chi Minh City. |
| doi_str_mv | 10.1099/jmm.0.010033-0 |
| format | Article |
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2 Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
3 Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
4 Hung Vuong Hospital, Ho Chi Minh City, Vietnam
5 Center for Poverty-related Communicable Diseases (CPCD), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Correspondence Constance Schultsz schultsz{at}gmail.com
Received February 4, 2009
Accepted August 14, 2009
Antimicrobial-resistant pathogenic members of the Enterobacteriaceae are a well-defined global problem. We hypothesized that one of the main reservoirs of dissemination of antimicrobial resistance genes in Vietnam is non-pathogenic intestinal flora, and sought to isolate antimicrobial-resistant organisms from hospitalized patients and non-hospitalized healthy individuals in Ho Chi Minh City. The results identified substantial faecal carriage of gentamicin-, ceftazidime- and nalidixic acid-resistant members of the Enterobacteriaceae in both hospitalized patients and non-hospitalized healthy individuals. A high prevalence of quinolone resistance determinants was identified, particularly the qnrS gene, in both community- and hospital-associated strains. Furthermore, the results demonstrated that a combination of quinolone resistance determinants can confer resistance to nalidixic acid and ciprofloxacin, even in the apparent absence of additional chromosomal resistance mutations in wild-type strains and laboratory strains with transferred plasmids. These data suggest that intestinal commensal organisms are a significant reservoir for the dissemination of plasmid-mediated quinolone resistance in Ho Chi Minh City.</description><identifier>ISSN: 0022-2615</identifier><identifier>EISSN: 1473-5644</identifier><identifier>DOI: 10.1099/jmm.0.010033-0</identifier><identifier>PMID: 19696153</identifier><identifier>CODEN: JMMIAV</identifier><language>eng</language><publisher>Reading: Soc General Microbiol</publisher><subject>Adult ; Anti-Bacterial Agents - pharmacology ; Antimicrobial Agents and Chemotherapy ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Bacteriology ; Biological and medical sciences ; Carrier State ; Child ; Child, Preschool ; Drug Resistance, Multiple, Bacterial - genetics ; Enterobacteriaceae - drug effects ; Enterobacteriaceae - genetics ; Enterobacteriaceae Infections - epidemiology ; Enterobacteriaceae Infections - microbiology ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Bacterial - physiology ; Humans ; Infant ; Infectious diseases ; Medical sciences ; Microbiology ; Miscellaneous ; Mutation ; Plasmids - genetics ; Quinolones - pharmacology ; Vietnam - epidemiology</subject><ispartof>Journal of medical microbiology, 2009-12, Vol.58 (12), p.1585-1592</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2009, SGM 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-682fcd0869b1b4fc09c1a0e5772f4547068be9fdada3ea190dfa8abbb27117c53</citedby><cites>FETCH-LOGICAL-c519t-682fcd0869b1b4fc09c1a0e5772f4547068be9fdada3ea190dfa8abbb27117c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3733,3734,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22189822$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19696153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minh Vien, Le Thi</creatorcontrib><creatorcontrib>Baker, Stephen</creatorcontrib><creatorcontrib>Phuong Thao, Le Thi</creatorcontrib><creatorcontrib>Phuong Tu, Le Thi</creatorcontrib><creatorcontrib>Thu Thuy, Cao</creatorcontrib><creatorcontrib>Thu Nga, Tran Thi</creatorcontrib><creatorcontrib>Minh Hoang, Nguyen Van</creatorcontrib><creatorcontrib>Campbell, James Iain</creatorcontrib><creatorcontrib>Minh Yen, Lam</creatorcontrib><creatorcontrib>Trong Hieu, Nguyen</creatorcontrib><creatorcontrib>Vinh Chau, Nguyen Van</creatorcontrib><creatorcontrib>Farrar, Jeremy</creatorcontrib><creatorcontrib>Schultsz, Constance</creatorcontrib><title>High prevalence of plasmid-mediated quinolone resistance determinants in commensal members of the Enterobacteriaceae in Ho Chi Minh City, Vietnam</title><title>Journal of medical microbiology</title><addtitle>J Med Microbiol</addtitle><description>1 Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
2 Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
3 Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
4 Hung Vuong Hospital, Ho Chi Minh City, Vietnam
5 Center for Poverty-related Communicable Diseases (CPCD), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Correspondence Constance Schultsz schultsz{at}gmail.com
Received February 4, 2009
Accepted August 14, 2009
Antimicrobial-resistant pathogenic members of the Enterobacteriaceae are a well-defined global problem. We hypothesized that one of the main reservoirs of dissemination of antimicrobial resistance genes in Vietnam is non-pathogenic intestinal flora, and sought to isolate antimicrobial-resistant organisms from hospitalized patients and non-hospitalized healthy individuals in Ho Chi Minh City. The results identified substantial faecal carriage of gentamicin-, ceftazidime- and nalidixic acid-resistant members of the Enterobacteriaceae in both hospitalized patients and non-hospitalized healthy individuals. A high prevalence of quinolone resistance determinants was identified, particularly the qnrS gene, in both community- and hospital-associated strains. Furthermore, the results demonstrated that a combination of quinolone resistance determinants can confer resistance to nalidixic acid and ciprofloxacin, even in the apparent absence of additional chromosomal resistance mutations in wild-type strains and laboratory strains with transferred plasmids. These data suggest that intestinal commensal organisms are a significant reservoir for the dissemination of plasmid-mediated quinolone resistance in Ho Chi Minh City.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antimicrobial Agents and Chemotherapy</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Carrier State</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Enterobacteriaceae - genetics</subject><subject>Enterobacteriaceae Infections - epidemiology</subject><subject>Enterobacteriaceae Infections - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Bacterial - physiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mutation</subject><subject>Plasmids - genetics</subject><subject>Quinolones - pharmacology</subject><subject>Vietnam - epidemiology</subject><issn>0022-2615</issn><issn>1473-5644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU2LFDEQhhtR3HH16lFyERHsMR_9kVwEGVZHWPGiXkMlXT2dpZPMJj0r-zP8x2aYYdVTQfLkrao8VfWS0TWjSr2_8X5N15RRKkRNH1Ur1vSibrumeVytKOW85h1rL6pnOd9Qynoh1NPqgqlOlWOxqn5v3W4i-4R3MGOwSOJI9jNk74ba4-BgwYHcHlyIcwxIEmaXFziCAy6YvAsQlkxcIDZ6jyHDTDx6gykfo5YJyVUoYDRgS3FgEfCIbyPZTI58dWEiG7fcvyM_HS4B_PPqyQhzxhfneln9-HT1fbOtr799_rL5eF3blqml7iQf7UBlpwwzzWipsgwotn3Px6ZtetpJg2ocYACBwBQdRpBgjOE9Y71txWX14ZS7P5iyqcWwJJj1PjkP6V5HcPr_m-AmvYt3mkvZKKFKwJtzQIq3B8yL9i5bnGcIGA9Zl7_umlZwVsj1ibQp5pxwfOjCqD5q1EWjpvqkUdPy4NW_s_3Fz94K8PoMQLYwj6kocfmB45xJJTkv3NsTNxXNv1xCvcPgXZnDuHjs2krNuGatbMUfUYu4nw</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Minh Vien, Le Thi</creator><creator>Baker, Stephen</creator><creator>Phuong Thao, Le Thi</creator><creator>Phuong Tu, Le Thi</creator><creator>Thu Thuy, Cao</creator><creator>Thu Nga, Tran Thi</creator><creator>Minh Hoang, Nguyen Van</creator><creator>Campbell, James Iain</creator><creator>Minh Yen, Lam</creator><creator>Trong Hieu, Nguyen</creator><creator>Vinh Chau, Nguyen Van</creator><creator>Farrar, Jeremy</creator><creator>Schultsz, Constance</creator><general>Soc General Microbiol</general><general>Society for General Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091201</creationdate><title>High prevalence of plasmid-mediated quinolone resistance determinants in commensal members of the Enterobacteriaceae in Ho Chi Minh City, Vietnam</title><author>Minh Vien, Le Thi ; Baker, Stephen ; Phuong Thao, Le Thi ; Phuong Tu, Le Thi ; Thu Thuy, Cao ; Thu Nga, Tran Thi ; Minh Hoang, Nguyen Van ; Campbell, James Iain ; Minh Yen, Lam ; Trong Hieu, Nguyen ; Vinh Chau, Nguyen Van ; Farrar, Jeremy ; Schultsz, Constance</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-682fcd0869b1b4fc09c1a0e5772f4547068be9fdada3ea190dfa8abbb27117c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antimicrobial Agents and Chemotherapy</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Carrier State</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>Enterobacteriaceae - drug effects</topic><topic>Enterobacteriaceae - genetics</topic><topic>Enterobacteriaceae Infections - epidemiology</topic><topic>Enterobacteriaceae Infections - microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Bacterial - physiology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mutation</topic><topic>Plasmids - genetics</topic><topic>Quinolones - pharmacology</topic><topic>Vietnam - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minh Vien, Le Thi</creatorcontrib><creatorcontrib>Baker, Stephen</creatorcontrib><creatorcontrib>Phuong Thao, Le Thi</creatorcontrib><creatorcontrib>Phuong Tu, Le Thi</creatorcontrib><creatorcontrib>Thu Thuy, Cao</creatorcontrib><creatorcontrib>Thu Nga, Tran Thi</creatorcontrib><creatorcontrib>Minh Hoang, Nguyen Van</creatorcontrib><creatorcontrib>Campbell, James Iain</creatorcontrib><creatorcontrib>Minh Yen, Lam</creatorcontrib><creatorcontrib>Trong Hieu, Nguyen</creatorcontrib><creatorcontrib>Vinh Chau, Nguyen Van</creatorcontrib><creatorcontrib>Farrar, Jeremy</creatorcontrib><creatorcontrib>Schultsz, Constance</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minh Vien, Le Thi</au><au>Baker, Stephen</au><au>Phuong Thao, Le Thi</au><au>Phuong Tu, Le Thi</au><au>Thu Thuy, Cao</au><au>Thu Nga, Tran Thi</au><au>Minh Hoang, Nguyen Van</au><au>Campbell, James Iain</au><au>Minh Yen, Lam</au><au>Trong Hieu, Nguyen</au><au>Vinh Chau, Nguyen Van</au><au>Farrar, Jeremy</au><au>Schultsz, Constance</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of plasmid-mediated quinolone resistance determinants in commensal members of the Enterobacteriaceae in Ho Chi Minh City, Vietnam</atitle><jtitle>Journal of medical microbiology</jtitle><addtitle>J Med Microbiol</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>58</volume><issue>12</issue><spage>1585</spage><epage>1592</epage><pages>1585-1592</pages><issn>0022-2615</issn><eissn>1473-5644</eissn><coden>JMMIAV</coden><abstract>1 Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
2 Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
3 Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
4 Hung Vuong Hospital, Ho Chi Minh City, Vietnam
5 Center for Poverty-related Communicable Diseases (CPCD), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Correspondence Constance Schultsz schultsz{at}gmail.com
Received February 4, 2009
Accepted August 14, 2009
Antimicrobial-resistant pathogenic members of the Enterobacteriaceae are a well-defined global problem. We hypothesized that one of the main reservoirs of dissemination of antimicrobial resistance genes in Vietnam is non-pathogenic intestinal flora, and sought to isolate antimicrobial-resistant organisms from hospitalized patients and non-hospitalized healthy individuals in Ho Chi Minh City. The results identified substantial faecal carriage of gentamicin-, ceftazidime- and nalidixic acid-resistant members of the Enterobacteriaceae in both hospitalized patients and non-hospitalized healthy individuals. A high prevalence of quinolone resistance determinants was identified, particularly the qnrS gene, in both community- and hospital-associated strains. Furthermore, the results demonstrated that a combination of quinolone resistance determinants can confer resistance to nalidixic acid and ciprofloxacin, even in the apparent absence of additional chromosomal resistance mutations in wild-type strains and laboratory strains with transferred plasmids. These data suggest that intestinal commensal organisms are a significant reservoir for the dissemination of plasmid-mediated quinolone resistance in Ho Chi Minh City.</abstract><cop>Reading</cop><pub>Soc General Microbiol</pub><pmid>19696153</pmid><doi>10.1099/jmm.0.010033-0</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of medical microbiology, 2009-12, Vol.58 (12), p.1585-1592 |
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| source | MEDLINE; Microbiology Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Anti-Bacterial Agents - pharmacology Antimicrobial Agents and Chemotherapy Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Carrier State Child Child, Preschool Drug Resistance, Multiple, Bacterial - genetics Enterobacteriaceae - drug effects Enterobacteriaceae - genetics Enterobacteriaceae Infections - epidemiology Enterobacteriaceae Infections - microbiology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial - physiology Humans Infant Infectious diseases Medical sciences Microbiology Miscellaneous Mutation Plasmids - genetics Quinolones - pharmacology Vietnam - epidemiology |
| title | High prevalence of plasmid-mediated quinolone resistance determinants in commensal members of the Enterobacteriaceae in Ho Chi Minh City, Vietnam |
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