Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved

Sebastien Gagneux and colleagues report the genome sequences of 21 phylogeographically diverse Mycobacterium tuberculosis complex strains. Analysis of the global genetic diversity of these strains showed that most of the known human T cell epitopes were highly conserved. Mycobacterium tuberculosis i...

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Veröffentlicht in:	Nature genetics 2010-06, Vol.42 (6), p.498-503
Hauptverfasser:	Comas, Iñaki, Chakravartti, Jaidip, Small, Peter M, Galagan, James, Niemann, Stefan, Kremer, Kristin, Ernst, Joel D, Gagneux, Sebastien
Format:	Artikel
Sprache:	eng
Schlagworte:	631/181/2474 631/208/325/2482 631/250/1619/554 Agriculture Animal Genetics and Genomics Antigenic determinants Antigens, Bacterial - genetics Bacteria Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Conserved Sequence Epitopes, T-Lymphocyte Evolution, Molecular Fundamental and applied biological sciences. Psychology Gene Function Genes Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Genome, Bacterial Health aspects Human Genetics Humans Mortality Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Phylogeny Physiological aspects Sequence Analysis, DNA Studies T cells T-Lymphocytes - immunology Tuberculosis
Online-Zugang:	Volltext
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