Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats

Abstract Social deprivation in early life disrupts emotionality and attentional processes in humans. Rearing rats in isolation reproduces some of these abnormalities, which are attenuated by daily handling. However, the neurochemical mechanisms underlying these responses remain poorly understood. We...

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Veröffentlicht in:	Neuroscience 2010-06, Vol.168 (2), p.371-386
Hauptverfasser:	Sciolino, N.R, Bortolato, M, Eisenstein, S.A, Fu, J, Oveisi, F, Hohmann, A.G, Piomelli, D
Format:	Artikel
Sprache:	eng
Schlagworte:	2-arachidonoylglycerol (2-AG) Adaptations Adult and adolescent clinical studies anandamide Animals Attention Behavior, Animal Biological and medical sciences Brain - metabolism Cannabinoid Receptor Modulators - physiology early-life stress emotionality Emotions Endocannabinoids Female Fundamental and applied biological sciences. Psychology handling Handling, Psychological Male Maze Learning Medical sciences Neurology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Rats Rats, Sprague-Dawley Receptors, Cannabinoid - metabolism Reflex, Startle Schizophrenia Signal Transduction Social Isolation Vertebrates: nervous system and sense organs
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