Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis

Astrocytes play a critical role in maintaining cerebral homeostasis and their dysregulation is thought to contribute to the pathogenesis of several diseases, including brain cancer and metastasis. Similar to the human disease, we found that lung and melanoma metastases in the mouse brain are accompa...

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Veröffentlicht in:	International journal of oncology 2009-10, Vol.35 (4), p.665-672
Hauptverfasser:	LANGLEY, Robert R, FAN, Dominic, LIXIA GUO, CHENYU ZHANG, QINGTANG LIN, BRANTLEY, Emily C, MCCARTY, Joseph H, FIDLER, Isaiah J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Animals Animals, Newborn Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Antigens, Polyomavirus Transforming - genetics Astrocytes - metabolism Astrocytes - pathology Biological and medical sciences Brain Neoplasms - metabolism Brain Neoplasms - secondary Cell Communication Cell Line Cell Proliferation Cell Survival Cell Transformation, Viral - genetics Coculture Techniques Excitatory Amino Acid Transporter 1 - metabolism Excitatory Amino Acid Transporter 2 - metabolism Glial Fibrillary Acidic Protein - metabolism H-2 Antigens - genetics Humans Lung Neoplasms - pathology Medical sciences Melanoma - pathology Mice Mice, Inbred C3H Mice, Nude Mice, Transgenic Neurology Receptors, N-Methyl-D-Aspartate - metabolism Temperature Time Factors Tumors Tumors of the nervous system. Phacomatoses
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