Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole

It has been reported that sensitivity to angiotensin II (Ang II) is higher in efferent (Ef) than afferent (Af) arterioles (Arts). We tested the hypothesis that this is due to arteriolar differences in the interaction between Ang II and endothelium-derived relaxing factor/nitric oxide (EDNO). Rabbit...

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Veröffentlicht in:	The Journal of clinical investigation 1993-05, Vol.91 (5), p.2012-2019
Hauptverfasser:	SADAYOSHI ITO, SHUJI ARIMA, YI LIN REN, JUNCOS, L. A, CARRETERO, O. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Arginine - analogs & derivatives Arginine - pharmacology Arterioles - drug effects Arterioles - physiology Biological and medical sciences Dose-Response Relationship, Drug Hematology In Vitro Techniques Investigative techniques, diagnostic techniques (general aspects) Kidney - blood supply Kinetics Male Medical sciences Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology NG-Nitroarginine Methyl Ester Nitric Oxide - metabolism Nitric Oxide - physiology Nitroarginine Norepinephrine - pharmacology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Perfusion Rabbits Vasoconstriction - drug effects
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