Bone morphogenetic protein expression in human atherosclerotic lesions
Artery wall calcification associated with atherosclerosis frequently contains fully formed bone tissue including marrow. The cellular origin is not known. In this study, bone morphogenetic protein-2a, a potent factor for osteoblastic differentiation, was found to be expressed in calcified human athe...
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| Veröffentlicht in: | The Journal of clinical investigation 1993-04, Vol.91 (4), p.1800-1809 |
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| container_title | The Journal of clinical investigation |
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| creator | BOSTRÖM, K WATSON, K. E HORN, S WORTHAM, C HERMAN, I. M DEMER, L. L |
| description | Artery wall calcification associated with atherosclerosis frequently contains fully formed bone tissue including marrow. The cellular origin is not known. In this study, bone morphogenetic protein-2a, a potent factor for osteoblastic differentiation, was found to be expressed in calcified human atherosclerotic plaque. In addition, cells cultured from the aortic wall formed calcified nodules similar to those found in bone cell cultures and expressed bone morphogenetic protein-2a with prolonged culture. The predominant cells in these nodules had immunocytochemical features characteristic of microvascular pericytes that are capable of osteoblastic differentiation. Pericyte-like cells were also found by immunohistochemistry in the intima of bovine and human aorta. These findings suggest that arterial calcification is a regulated process similar to bone formation, possibly mediated by pericyte-like cells. |
| doi_str_mv | 10.1172/jci116391 |
| format | Article |
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These findings suggest that arterial calcification is a regulated process similar to bone formation, possibly mediated by pericyte-like cells.</description><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/jci116391</identifier><identifier>PMID: 8473518</identifier><identifier>CODEN: JCINAO</identifier><language>eng</language><publisher>Ann Arbor, MI: American Society for Clinical Investigation</publisher><subject>Animals ; Aorta ; Arteriosclerosis - metabolism ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Bone Morphogenetic Proteins ; Cardiology. 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E</creatorcontrib><creatorcontrib>HORN, S</creatorcontrib><creatorcontrib>WORTHAM, C</creatorcontrib><creatorcontrib>HERMAN, I. M</creatorcontrib><creatorcontrib>DEMER, L. L</creatorcontrib><title>Bone morphogenetic protein expression in human atherosclerotic lesions</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>Artery wall calcification associated with atherosclerosis frequently contains fully formed bone tissue including marrow. The cellular origin is not known. In this study, bone morphogenetic protein-2a, a potent factor for osteoblastic differentiation, was found to be expressed in calcified human atherosclerotic plaque. In addition, cells cultured from the aortic wall formed calcified nodules similar to those found in bone cell cultures and expressed bone morphogenetic protein-2a with prolonged culture. The predominant cells in these nodules had immunocytochemical features characteristic of microvascular pericytes that are capable of osteoblastic differentiation. Pericyte-like cells were also found by immunohistochemistry in the intima of bovine and human aorta. These findings suggest that arterial calcification is a regulated process similar to bone formation, possibly mediated by pericyte-like cells.</description><subject>Animals</subject><subject>Aorta</subject><subject>Arteriosclerosis - metabolism</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Bone Morphogenetic Proteins</subject><subject>Cardiology. Vascular system</subject><subject>Cattle</subject><subject>Fluorescent Antibody Technique</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Muscle, Smooth, Vascular - cytology</subject><subject>Proteins - physiology</subject><subject>RNA Probes</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1P3DAQhq2qiC6UQ39ApRwqJA4pHn_Fe-AAq1JASFzK2XKcMWuU2MHOVvTfN6tdrdrLjEbvM18vIV-Afgdo2OWrCwCKL-EDWYCUutaM649kQSmDetlw_YmclPJKKQghxTE51qLhEvSC3N6kiNWQ8rhOLxhxCq4ac5owxArfx4ylhBSruVpvBhsrO60xp-L6OW7ZHrd6-UyOvO0Lnu3zKXm-_fFrdVc_Pv28X10_1k5SMdXAW9ugoKA7bSnTEnnr21YtPbMC0YKwXCrvlw0o1fG2E7zzzKNHq9FxwU_J1W7uuGkH7BzGKdvejDkMNv8xyQbzvxLD2ryk34ZpDQrm_vN9f05vGyyTGUJx2Pc2YtoU00jVKKrkDF7sQDd_WzL6ww6gZuu5eVjd7zyf2a__HnUg9ybP-re9bouzvc82ulAOmGiYZEzyv3BajDM</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>BOSTRÖM, K</creator><creator>WATSON, K. 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L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-13ba7e4018d8a0285e3bfbb69f2a4eea14a356ff97166d3bd43df2fefea8ec343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Aorta</topic><topic>Arteriosclerosis - metabolism</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Bone Morphogenetic Proteins</topic><topic>Cardiology. Vascular system</topic><topic>Cattle</topic><topic>Fluorescent Antibody Technique</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Muscle, Smooth, Vascular - cytology</topic><topic>Proteins - physiology</topic><topic>RNA Probes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOSTRÖM, K</creatorcontrib><creatorcontrib>WATSON, K. E</creatorcontrib><creatorcontrib>HORN, S</creatorcontrib><creatorcontrib>WORTHAM, C</creatorcontrib><creatorcontrib>HERMAN, I. M</creatorcontrib><creatorcontrib>DEMER, L. 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L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone morphogenetic protein expression in human atherosclerotic lesions</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>91</volume><issue>4</issue><spage>1800</spage><epage>1809</epage><pages>1800-1809</pages><issn>0021-9738</issn><eissn>1558-8238</eissn><coden>JCINAO</coden><abstract>Artery wall calcification associated with atherosclerosis frequently contains fully formed bone tissue including marrow. The cellular origin is not known. In this study, bone morphogenetic protein-2a, a potent factor for osteoblastic differentiation, was found to be expressed in calcified human atherosclerotic plaque. In addition, cells cultured from the aortic wall formed calcified nodules similar to those found in bone cell cultures and expressed bone morphogenetic protein-2a with prolonged culture. 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| subjects | Animals Aorta Arteriosclerosis - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Bone Morphogenetic Proteins Cardiology. Vascular system Cattle Fluorescent Antibody Technique Humans Immunohistochemistry In Situ Hybridization Medical sciences Microscopy, Electron Muscle, Smooth, Vascular - cytology Proteins - physiology RNA Probes |
| title | Bone morphogenetic protein expression in human atherosclerotic lesions |
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