Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide

Abstract Interleukin (IL)-10 is important for regulating inflammation but whether it protects against infection-related deficits in cognitive function is unknown. Therefore, the current study evaluated sickness behavior, hippocampal-dependent matching-to-place performance and several inflammatory cy...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2009-08, Vol.23 (6), p.794-802
Hauptverfasser:	Richwine, Amy F, Sparkman, Nathan L, Dilger, Ryan N, Buchanan, Jessica B, Johnson, Rodney W
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Behavior Behavior - physiology Cognition Disorders - chemically induced Cognition Disorders - psychology Corticosterone - blood Cytokines Cytokines - biosynthesis Cytokines - genetics Dendrites - drug effects Dendrites - ultrastructure Hippocampus Injections, Intraperitoneal Interleukin-10 Interleukin-10 - genetics Interleukin-10 - physiology Lipopolysaccharides - administration & dosage Lipopolysaccharides - pharmacology Male Maze Learning - drug effects Mice Mice, Inbred C57BL Mice, Knockout Motor Activity - drug effects Motor Activity - physiology Nerve Growth Factors - biosynthesis Nerve Growth Factors - genetics Psychiatry Psychomotor Performance - physiology Pyramidal Cells - drug effects Pyramidal Cells - ultrastructure RNA, Messenger - biosynthesis RNA, Messenger - genetics Working memory
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