Effect of excess α-hemoglobin chains on cellular and membrane oxidation in model β-thalassemic erythrocytes

While red cells from individuals with beta thalassemias are characterized by evidence of elevated in vivo oxidation, it has not been possible to directly examine the relationship between excess alpha-hemoglobin chains and the observed oxidant damage. To investigate the oxidative effects of unpaired...

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Veröffentlicht in:	The Journal of clinical investigation 1993-04, Vol.91 (4), p.1706-1712
Hauptverfasser:	SCOTT, M. D, VAN DEN BERG, J. J. M, REPKA, T, ROUYER-FESSARD, P, HEBBEL, R. P, BEUZARD, Y, LUBIN, B. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitrole - pharmacology Anemias. Hemoglobinopathies Antioxidants - pharmacology beta-Thalassemia - blood Biological and medical sciences Deferoxamine - pharmacology Dextrans - pharmacology Diseases of red blood cells Erythrocyte Deformability - drug effects Erythrocyte Membrane - metabolism Erythrocytes - chemistry Glutathione - blood Hematologic and hematopoietic diseases Heme - metabolism Hemoglobins - chemistry Hemoglobins - metabolism Hemoglobins - pharmacology Humans Iron - metabolism Lipid Peroxidation Mass Spectrometry Medical sciences Membrane Proteins - metabolism Oxidation-Reduction Peroxides - metabolism Reactive Oxygen Species - metabolism
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