Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer
Breast cancers related to BRCA mutations are associated with particular biological features. Here we report the clinical and pathological characteristics of breast cancer in Chinese women with and without BRCA mutations and of carriers of BRCA1 mutations compared to BRCA2 mutations. Two hundred and...
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| creator | Kwong, Ava Wong, L. P. Wong, H. N. Law, F. B. F. Ng, E. K. O. Tang, Y. H. Chan, W. K. Suen, D. T. K. Choi, C. Ho, L. S. Kwan, K. H. Poon, M. Wong, T. T. Chan, K. Chan, S. W. W. Ying, M. W. L. Chan, W. C. Ma, E. S. K. Ford, J. M. West, D. W. |
| description | Breast cancers related to
BRCA
mutations are associated with particular biological features. Here we report the clinical and pathological characteristics of breast cancer in Chinese women with and without
BRCA
mutations and of carriers of
BRCA1
mutations compared to
BRCA2
mutations. Two hundred and 26 high-risk Hong Kong Chinese women were tested for
BRCA
mutations, medical information was obtained from medical records, and risk and demographic information was obtained from personal interviews. In this cohort, 28 (12.4%) women were
BRCA
mutation carriers and among these carriers, 39.3% were
BRCA1
and 60.7% were
BRCA2
mutations. Mutation carriers were more likely to have a familial history of breast and ovarian cancer, high-grade cancers, and triple negative (TN) cancers. Prevalence of TN was 48.3% in
BRCA
carriers and 25.6% in non-carriers and was 67.7% in
BRCA1
and 35.3% in
BRCA2
carriers. Estrogen receptor (ER) negative cancer was significantly associated with
BRCA1
mutations, especially in those under 40 years of age.
BRCA
-related breast cancer in this Chinese population is associated with family history and adverse pathological/prognostic features, with
BRCA2
mutations being more prevalent but
BRCA1
carriers having more aggressive and TN cancers. Compared to Caucasian populations, prevalence of
BRCA2
mutations and TN cancer in BRCA2 mutation carriers in Chinese population are elevated. |
| doi_str_mv | 10.1007/s11568-010-9136-z |
| format | Article |
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BRCA
mutations are associated with particular biological features. Here we report the clinical and pathological characteristics of breast cancer in Chinese women with and without
BRCA
mutations and of carriers of
BRCA1
mutations compared to
BRCA2
mutations. Two hundred and 26 high-risk Hong Kong Chinese women were tested for
BRCA
mutations, medical information was obtained from medical records, and risk and demographic information was obtained from personal interviews. In this cohort, 28 (12.4%) women were
BRCA
mutation carriers and among these carriers, 39.3% were
BRCA1
and 60.7% were
BRCA2
mutations. Mutation carriers were more likely to have a familial history of breast and ovarian cancer, high-grade cancers, and triple negative (TN) cancers. Prevalence of TN was 48.3% in
BRCA
carriers and 25.6% in non-carriers and was 67.7% in
BRCA1
and 35.3% in
BRCA2
carriers. Estrogen receptor (ER) negative cancer was significantly associated with
BRCA1
mutations, especially in those under 40 years of age.
BRCA
-related breast cancer in this Chinese population is associated with family history and adverse pathological/prognostic features, with
BRCA2
mutations being more prevalent but
BRCA1
carriers having more aggressive and TN cancers. Compared to Caucasian populations, prevalence of
BRCA2
mutations and TN cancer in BRCA2 mutation carriers in Chinese population are elevated.</description><identifier>ISSN: 1877-6558</identifier><identifier>EISSN: 1877-6566</identifier><identifier>DOI: 10.1007/s11568-010-9136-z</identifier><identifier>PMID: 20535403</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Health Promotion and Disease Prevention ; Human Genetics ; Internal Medicine ; Molecular Medicine ; Public Health ; Research Article</subject><ispartof>The HUGO journal, 2009-12, Vol.3 (1-4), p.63-76</ispartof><rights>The Author(s) 2010</rights><rights>Springer Science+Business Media B.V. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384z-d233f959f162e0f2e423a656c2c0d9e7065170eec4e3044c141e72318f8e65453</citedby><cites>FETCH-LOGICAL-c384z-d233f959f162e0f2e423a656c2c0d9e7065170eec4e3044c141e72318f8e65453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881322/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881322/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41096,41464,42165,42533,51294,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20535403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwong, Ava</creatorcontrib><creatorcontrib>Wong, L. P.</creatorcontrib><creatorcontrib>Wong, H. N.</creatorcontrib><creatorcontrib>Law, F. B. F.</creatorcontrib><creatorcontrib>Ng, E. K. O.</creatorcontrib><creatorcontrib>Tang, Y. H.</creatorcontrib><creatorcontrib>Chan, W. K.</creatorcontrib><creatorcontrib>Suen, D. T. K.</creatorcontrib><creatorcontrib>Choi, C.</creatorcontrib><creatorcontrib>Ho, L. S.</creatorcontrib><creatorcontrib>Kwan, K. H.</creatorcontrib><creatorcontrib>Poon, M.</creatorcontrib><creatorcontrib>Wong, T. T.</creatorcontrib><creatorcontrib>Chan, K.</creatorcontrib><creatorcontrib>Chan, S. W. W.</creatorcontrib><creatorcontrib>Ying, M. W. L.</creatorcontrib><creatorcontrib>Chan, W. C.</creatorcontrib><creatorcontrib>Ma, E. S. K.</creatorcontrib><creatorcontrib>Ford, J. M.</creatorcontrib><creatorcontrib>West, D. W.</creatorcontrib><title>Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer</title><title>The HUGO journal</title><addtitle>HUGO J</addtitle><addtitle>Hugo J</addtitle><description>Breast cancers related to
BRCA
mutations are associated with particular biological features. Here we report the clinical and pathological characteristics of breast cancer in Chinese women with and without
BRCA
mutations and of carriers of
BRCA1
mutations compared to
BRCA2
mutations. Two hundred and 26 high-risk Hong Kong Chinese women were tested for
BRCA
mutations, medical information was obtained from medical records, and risk and demographic information was obtained from personal interviews. In this cohort, 28 (12.4%) women were
BRCA
mutation carriers and among these carriers, 39.3% were
BRCA1
and 60.7% were
BRCA2
mutations. Mutation carriers were more likely to have a familial history of breast and ovarian cancer, high-grade cancers, and triple negative (TN) cancers. Prevalence of TN was 48.3% in
BRCA
carriers and 25.6% in non-carriers and was 67.7% in
BRCA1
and 35.3% in
BRCA2
carriers. Estrogen receptor (ER) negative cancer was significantly associated with
BRCA1
mutations, especially in those under 40 years of age.
BRCA
-related breast cancer in this Chinese population is associated with family history and adverse pathological/prognostic features, with
BRCA2
mutations being more prevalent but
BRCA1
carriers having more aggressive and TN cancers. Compared to Caucasian populations, prevalence of
BRCA2
mutations and TN cancer in BRCA2 mutation carriers in Chinese population are elevated.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Health Promotion and Disease Prevention</subject><subject>Human Genetics</subject><subject>Internal Medicine</subject><subject>Molecular Medicine</subject><subject>Public Health</subject><subject>Research Article</subject><issn>1877-6558</issn><issn>1877-6566</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kV9rFDEUxQdRbKn9AL5IwAefpt78z7wIddAqFATRRwlp5s5OymyyJrMV99ObdetSBfOSkPu7J_fkNM1zChcUQL8ulEplWqDQdpSrdveoOaVG61ZJpR4fz9KcNOel3EJdnHUg-NPmhIHkUgA_bb71c4jBu5m4OJCNW6Y0p9XvCz-57PyCOZQl-ELSSPopRCy45wLGpZAfYZnI28_9Jck4uwUHcpPRlYV4Fz3mZ82T0c0Fz-_3s-br-3df-g_t9aerj_3ldeu5Ebt2YJyPnexGqhjCyFAw7qoNzzwMHWpQkmpA9AI5COGpoKgZp2Y0qKSQ_Kx5c9DdbG_WOPg6W3az3eSwdvmnTS7YvysxTHaV7iwzhnLGqsCre4Gcvm-xLHYdisd5dhHTtljNOVNglK7ky3_I27TNsbqzVNf_VQBMVIoeKJ9TKRnH4ywU7D4-e4jP1vjsPj67qz0vHpo4dvwJqwLsAJRaiivMD57-r-ovWqalwA</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Kwong, Ava</creator><creator>Wong, L. 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W.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>Springer Netherlands</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200912</creationdate><title>Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer</title><author>Kwong, Ava ; Wong, L. P. ; Wong, H. N. ; Law, F. B. F. ; Ng, E. K. O. ; Tang, Y. H. ; Chan, W. K. ; Suen, D. T. K. ; Choi, C. ; Ho, L. S. ; Kwan, K. H. ; Poon, M. ; Wong, T. T. ; Chan, K. ; Chan, S. W. W. ; Ying, M. W. L. ; Chan, W. C. ; Ma, E. S. K. ; Ford, J. 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W.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The HUGO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwong, Ava</au><au>Wong, L. P.</au><au>Wong, H. N.</au><au>Law, F. B. F.</au><au>Ng, E. K. O.</au><au>Tang, Y. H.</au><au>Chan, W. K.</au><au>Suen, D. T. K.</au><au>Choi, C.</au><au>Ho, L. S.</au><au>Kwan, K. H.</au><au>Poon, M.</au><au>Wong, T. T.</au><au>Chan, K.</au><au>Chan, S. W. W.</au><au>Ying, M. W. L.</au><au>Chan, W. C.</au><au>Ma, E. S. K.</au><au>Ford, J. M.</au><au>West, D. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer</atitle><jtitle>The HUGO journal</jtitle><stitle>HUGO J</stitle><addtitle>Hugo J</addtitle><date>2009-12</date><risdate>2009</risdate><volume>3</volume><issue>1-4</issue><spage>63</spage><epage>76</epage><pages>63-76</pages><issn>1877-6558</issn><eissn>1877-6566</eissn><abstract>Breast cancers related to
BRCA
mutations are associated with particular biological features. Here we report the clinical and pathological characteristics of breast cancer in Chinese women with and without
BRCA
mutations and of carriers of
BRCA1
mutations compared to
BRCA2
mutations. Two hundred and 26 high-risk Hong Kong Chinese women were tested for
BRCA
mutations, medical information was obtained from medical records, and risk and demographic information was obtained from personal interviews. In this cohort, 28 (12.4%) women were
BRCA
mutation carriers and among these carriers, 39.3% were
BRCA1
and 60.7% were
BRCA2
mutations. Mutation carriers were more likely to have a familial history of breast and ovarian cancer, high-grade cancers, and triple negative (TN) cancers. Prevalence of TN was 48.3% in
BRCA
carriers and 25.6% in non-carriers and was 67.7% in
BRCA1
and 35.3% in
BRCA2
carriers. Estrogen receptor (ER) negative cancer was significantly associated with
BRCA1
mutations, especially in those under 40 years of age.
BRCA
-related breast cancer in this Chinese population is associated with family history and adverse pathological/prognostic features, with
BRCA2
mutations being more prevalent but
BRCA1
carriers having more aggressive and TN cancers. Compared to Caucasian populations, prevalence of
BRCA2
mutations and TN cancer in BRCA2 mutation carriers in Chinese population are elevated.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>20535403</pmid><doi>10.1007/s11568-010-9136-z</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature - Complete Springer Journals; PubMed Central; Springer Nature OA Free Journals |
| subjects | Biomedical and Life Sciences Biomedicine Breast cancer Health Promotion and Disease Prevention Human Genetics Internal Medicine Molecular Medicine Public Health Research Article |
| title | Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer |
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